Department of Medicine III, Cardiology/Angiology/Nephrology, Goethe University Hospital, 60590, Frankfurt am Main, Germany.
Institute for Cardiovascular Regeneration, Goethe University, 60590, Frankfurt am Main, Germany.
Basic Res Cardiol. 2024 Jun;119(3):349-369. doi: 10.1007/s00395-024-01049-x. Epub 2024 Apr 29.
Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult heart to regenerate has posed challenges in finding effective treatments for cardiac pathologies. While various medications and surgical interventions have been used to improve cardiac function, they are not able to address the extensive loss of functioning cardiomyocytes that occurs during cardiac injury. As a result, there is growing interest in understanding how the cell cycle is regulated and exploring the potential for stimulating cardiomyocyte proliferation as a means of promoting heart regeneration. This review aims to provide an overview of current knowledge on cell cycle regulation and mechanisms underlying cardiomyocyte proliferation in cases of heart failure, while also highlighting established and novel therapeutic strategies targeting this area for treatment purposes.
心力衰竭仍然是一个重大的全球健康问题，导致了大量的发病率和死亡率。成人心脏的再生能力有限，这给寻找心脏病变的有效治疗方法带来了挑战。虽然已经使用了各种药物和手术干预来改善心脏功能，但它们无法解决心脏损伤时发生的大量功能失调的心肌细胞的损失。因此，人们越来越关注了解细胞周期是如何调节的，并探索刺激心肌细胞增殖以促进心脏再生的潜力。本综述旨在概述心力衰竭中心肌细胞增殖的细胞周期调控和机制的现有知识，同时强调针对该领域的既定和新型治疗策略。
