Jasni Nurhana, Saidin Syazwan, Arifin Norsyahida, Azman Daruliza Kernain, Shin Lai Ngit, Othman Nurulhasanah
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Gelugor 11800, Malaysia.
Department of Biology, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjung Malim 35900, Malaysia.
Membranes (Basel). 2022 Apr 1;12(4):396. doi: 10.3390/membranes12040396.
Amoebiasis is the third most common parasitic cause of morbidity and mortality, particularly in countries with poor hygienic settings in central and south America, Africa, and India. This disease is caused by a protozoan parasite, namely , which infects approximately 50 million people worldwide, resulting in 70,000 deaths every year. Since the 1960s, infection has been successfully treated with metronidazole. However, there are drawbacks to metronidazole therapy: the side effects, duration of treatment, and need for additional drugs to prevent transmission. Previous interdisciplinary studies, including biophysics, bioinformatics, chemistry, and, more recently, lipidomics studies, have increased biomembranes' publicity. The biological membranes are comprised of a mixture of membrane and cytosolic proteins. They work hand in hand mainly at the membrane part. They act as dedicated platforms for a whole range of cellular processes, such as cell proliferation, adhesion, migration, and intracellular trafficking, thus are appealing targets for drug treatment. Therefore, this review aims to observe the updated trend of the research regarding the biological membranes of from 2015 to 2021, which may help further research regarding the drug targeting the biological membrane.
阿米巴病是发病率和死亡率的第三大常见寄生虫病因，尤其是在中美洲、南美洲、非洲和印度卫生条件较差的国家。这种疾病由一种原生动物寄生虫引起，即 ，全球约有5000万人感染该寄生虫，每年导致7万人死亡。自20世纪60年代以来，甲硝唑已成功用于治疗 感染。然而，甲硝唑治疗存在一些缺点：副作用、治疗持续时间以及需要额外药物来预防传播。先前的跨学科研究，包括生物物理学、生物信息学、化学以及最近的脂质组学研究，提高了生物膜的关注度。生物膜由膜蛋白和胞质蛋白混合组成。它们主要在膜部分协同作用。它们作为一系列细胞过程的专用平台，如细胞增殖、黏附、迁移和细胞内运输，因此是药物治疗的有吸引力的靶点。因此，本综述旨在观察2015年至2021年关于 生物膜的研究的最新趋势，这可能有助于进一步开展针对生物膜的药物研究。 （注：原文中“namely ”后缺少具体寄生虫名称，“ from 2015 to 2021”中第一个“ ”也缺少具体内容，翻译时保留原文格式。）
