Moog Fabien, Mivielle Johanna, Brun Jessie, Dumitrache Mirabela Oana, Amalric Nicolas, Lecru Line-Alice, Pressanti Charline, Kondratjeva Jevgenija, Combarros Daniel, Fantini Oscar, Cadiergues Marie Christine
Department of Clinical Sciences, Université de Toulouse, ENVT, 31076 Toulouse, France.
Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania.
Vet Sci. 2022 Apr 13;9(4):185. doi: 10.3390/vetsci9040185.
Erythemato-ceruminous otitis externa (ECOE) is the most common type of otitis in dogs and is generally associated with bacterial and/or yeast infections. The performance of an ear cleaner was assessed over two weeks in canine ECOE, associated with a mild or moderate secondary infection, in a prospective open-label study. Forty ear canals with ECOE that did not receive any type of aural treatment and were not cleaned for 7 days were included. Pruritus (PS), 0−3 Otitis Index Score (OTIS-3) and 0−4 scale cytology (CYTO) scores were assessed on Day (D) 0, D7 and D14. Concentrations of a panel of 13 cytokines on the ear canal surface and the lipid profile of the exudate were measured on D0 and D14. From D0 to D12 or D13, the dogs’ ears were cleaned daily if the secretion score (SEC) was 3/3, every second day if the score was 2/3 and every third day if the score was 1/3. PS, OTIS-3, SEC and CYTO were significantly lower on D7 compared to baseline (−40%, −31%, −36%, −34%, respectively; p < 0.0001). The same parameters decreased further on D14 (−60%, −53%, −61%, −73%, respectively; p < 0.0001) and amounts of interleukin 8 and chemokine KC-like were also reduced compared to baseline (−45%, p < 0.01; −36%, p = 0.3, respectively). The lipid profile was also modified, with a decrease in free lipids and an increase in bound lipids.
红斑性耳垢性外耳炎（ECOE）是犬类中最常见的耳部疾病类型，通常与细菌和/或酵母菌感染有关。在一项前瞻性开放标签研究中，对一种耳部清洁剂在患有轻度或中度继发性感染的犬类ECOE中的使用效果进行了为期两周的评估。纳入了40只患有ECOE且未接受任何耳部治疗且7天未清洁的耳道。在第0天、第7天和第14天评估瘙痒（PS）、0 - 3中耳炎指数评分（OTIS - 3）和0 - 4级细胞学（CYTO）评分。在第0天和第14天测量耳道表面一组13种细胞因子的浓度以及渗出液的脂质谱。从第0天到第12天或第13天，如果分泌评分（SEC）为3/3，则每天清洁犬耳；如果评分为2/3，则每隔一天清洁一次；如果评分为1/3，则每隔三天清洁一次。与基线相比，第7天时PS、OTIS - 3、SEC和CYTO显著降低（分别降低40%、31%、36%、34%；p < 0.0001）。在第14天时，相同参数进一步降低（分别降低60%、53%、61%、73%；p < 0.0001），与基线相比，白细胞介素8和趋化因子KC样物质的量也减少（分别降低45%，p < 0.01；降低36%，p = 0.3）。脂质谱也发生了改变，游离脂质减少，结合脂质增加。
