Rème C A, Pin D, Collinot C, Cadiergues M C, Joyce J A, Fontaine J
Medical Department, Virbac Laboratories, 13eme rue LID, BP 27, F-06511 Carros, France.
Vet Ther. 2006 Spring;7(1):15-26.
A new antimicrobial ear cleanser was evaluated for the treatment of bacterial and yeast ear infection in dogs. Forty-five dogs with erythemato-ceruminous or purulent otitis externa were randomly allocated to two treatment groups: reference ear cleanser (Epiotic, Virbac) or test ear cleanser (Epiotic Advanced, Virbac). Ear cleansing was performed twice daily for 2 weeks, and no other treatment was allowed. By week 2, clinical (exudate quantity, erythema, stenosis, excoriation, and odor) and discomfort (pain, ear scratching, and head shaking) scores were significantly decreased (P < .0001 for all) and no microbial overgrowth could be detected in 25 (64.1%) and 32 (68.1%) ears treated with Epiotic and Epiotic Advanced, respectively. The new pH-balanced, propylene glycol-free test ear cleanser, which incorporates microbial adhesin-blocking carbohydrates, proved as effective as the reference acidic formula.
一种新型抗菌耳部清洁液被用于评估其对犬类细菌性和酵母菌性耳部感染的治疗效果。45只患有红斑性耵聍性或化脓性外耳炎的犬被随机分为两个治疗组：对照耳部清洁液（伊皮奥，维克公司）或试验耳部清洁液（伊皮奥高级版，维克公司）。耳部清洁每天进行两次，持续2周，不允许进行其他治疗。到第2周时，临床（渗出物量、红斑、狭窄、擦伤和气味）和不适（疼痛、耳部抓挠和摇头）评分显著降低（所有评分P <.0001），分别用伊皮奥和伊皮奥高级版治疗的25只（64.1%）和32只（68.1%）耳朵未检测到微生物过度生长。这种新型pH平衡、不含丙二醇的试验耳部清洁液含有能阻断微生物粘附的碳水化合物，其效果与对照酸性配方一样有效。
