Second Department of Urology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland.
Department of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, 50-556 Wrocław, Poland.
Tomography. 2022 Apr 11;8(2):1090-1096. doi: 10.3390/tomography8020089.
We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed by salvage lymph node dissection (SLND) in three academic centers between 2013 and 2020. A total of 27 men were included in the analyses. Sensitivity, specificity, positive and negative predictive values, and accuracy of choline-PET/CT in predicting pathology-proven lymph node involvement were 75%, 43%, 79%, 38% and 67% on per-patient and 70%, 86%, 80%, 78%, and 79% on per-site analyses, respectively, with the differences in specificity and NPV between per-patient and per-site analyses being statistically significant ( = 0.03 and 0.04, respectively). The study provides further insight into the role of preoperative choline-PET/CT in patients undergoing SLND for recurrent PC.
我们旨在回顾性分析 2013 年至 2020 年间在三个学术中心，对因局部治疗（有治愈倾向）后生化或临床复发且无远处转移证据的前列腺癌患者进行正电子发射断层扫描/计算机断层扫描（PET/CT）检查，这些患者行胆碱 PET/CT 检查后行挽救性淋巴结切除术（SLND）。共纳入 27 名男性进行分析。在单患者和单部位分析中，胆碱-PET/CT 预测病理证实的淋巴结受累的灵敏度、特异性、阳性预测值、阴性预测值和准确率分别为 75%、43%、79%、38%和 67%和 70%、86%、80%、78%和 79%，单患者和单部位分析之间的特异性和 NPV 的差异具有统计学意义（=0.03 和 0.04）。该研究进一步探讨了术前胆碱-PET/CT 在接受复发 PC 行 SLND 的患者中的作用。
