Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Mol Biol Rep. 2022 May;49(5):4025-4038. doi: 10.1007/s11033-022-07122-9. Epub 2022 Apr 21.
In patients with kidney injury, muscle mass and strength decrease with altered muscle protein synthesis and degradation along with complications such as inflammation and low physical activity. A treatment strategy to maintain muscle metabolism in kidney injury is important. One of the proposed strategies in this regard is exercise, which in addition to inducing muscle hypertrophy, reducing plasma creatinine and urea and decreasing the severity of tubal injuries, can boost immune function and has anti-inflammatory effects. One of the molecules that have been considered as a target in the treatment of many diseases is silent information regulator 1 (SIRT1). Exercise increases the expression of SIRT1 and improves its activity. Therefore, studies that examined the effect of exercise on kidney injury considering the role of SIRT1 in this effect were reviewed to determine the direction of kidney injury research in future regarding to its prevalence, especially following diabetes, and lack of definitive treatment. In this review, we found that SIRT1 can be one of renoprotective target pathways of exercise. However, further studies are needed to determine the role of SIRT1 in different kidney injuries following exercise according to the type and severity of exercise, and the type of kidney injury.
在肾脏损伤患者中，肌肉质量和力量会下降，同时伴随着肌肉蛋白合成和降解的改变以及炎症和低身体活动等并发症。维持肾脏损伤中肌肉代谢的治疗策略很重要。在这方面提出的策略之一是运动，除了诱导肌肉肥大、降低血浆肌酐和尿素以及减少肾小管损伤的严重程度外，还可以增强免疫功能并具有抗炎作用。沉默信息调节因子 1（SIRT1）是一种被认为是许多疾病治疗靶点的分子。运动可增加 SIRT1 的表达并提高其活性。因此，综述了考虑 SIRT1 在这种作用中的作用的关于运动对肾脏损伤影响的研究，以确定未来针对其普遍性的肾脏损伤研究方向，特别是在糖尿病和缺乏明确治疗方法之后。在这篇综述中，我们发现 SIRT1 可能是运动的肾脏保护靶途径之一。然而，需要进一步的研究来确定 SIRT1 在不同类型和严重程度的运动后不同类型的肾脏损伤中的作用。
