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创伤性脑损伤后口腔黏膜间充质干细胞的处方改善了肾脏和心脏的炎症和氧化应激。

The Prescription of Oral Mucosal Mesenchymal Stem Cells post-Traumatic Brain Injury Improved the Kidney and Heart Inflammation and Oxidative Stress.

机构信息

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

Biomed Res Int. 2022 Nov 10;2022:8235961. doi: 10.1155/2022/8235961. eCollection 2022.

DOI:10.1155/2022/8235961
PMID:36408281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9671733/
Abstract

BACKGROUND

In the last years, mesenchymal stem cells (MSCs) have been considered as a useful strategy to treat many diseases such as traumatic brain injury (TBI). The production of inflammatory agents by TBI elicits an inflammatory response directed to other systems of body, such as the heart and the kidneys. In this study, the efficacy of oral mucosal mesenchymal stem cells (OMSCs) prescription after TBI in inflammation and oxidative stress of the heart and kidneys was evaluated.

METHODS

Twenty-four male rats were located in groups as follows: sham, TBI, vehicle (Veh), and stem cell (SC). OMSCs were injected intravenously 1 and 24 hours after TBI. Inflammatory, oxidative stress, and histopathological outcomes of the heart and kidney tissues were investigated 48 hours after TBI.

RESULTS

TBI caused an increase in the level of interleukin-1 (IL-1), interleukin-6 (IL-6), malondialdehyde (MDA), and carbonyl protein (PC) of the heart and kidney compared to the sham group. Superoxide dismutase (SOD), total antioxidant capacity (TAC), catalase (CAT), and interleukin-10 (IL-10) of the heart and kidney decreased after TBI. The use of OMSCs after TBI reduced the changes of these factors in both the heart and the kidney.

CONCLUSION

Application of OMSCs after TBI can decrease inflammation and oxidative stress of the heart and kidney tissues leading to the reduction of damage. Therefore, this method can be evaluated in the TBI patients in future studies.

摘要

背景

近年来，间充质干细胞（MSCs）被认为是治疗创伤性脑损伤（TBI）等多种疾病的有效策略。TBI 产生的炎症介质会引发针对身体其他系统（如心脏和肾脏）的炎症反应。在这项研究中，评估了 TBI 后口腔黏膜间充质干细胞（OMSCs）处方对心脏和肾脏炎症和氧化应激的疗效。

方法

24 只雄性大鼠分为以下几组：假手术组、TBI 组、载体组（Veh）和干细胞组（SC）。TBI 后 1 小时和 24 小时静脉注射 OMSCs。TBI 后 48 小时检测心脏和肾脏组织的炎症、氧化应激和组织病理学结果。

结果

与假手术组相比，TBI 导致心脏和肾脏中白细胞介素-1（IL-1）、白细胞介素-6（IL-6）、丙二醛（MDA）和羰基蛋白（PC）水平升高。TBI 后心脏和肾脏中的超氧化物歧化酶（SOD）、总抗氧化能力（TAC）、过氧化氢酶（CAT）和白细胞介素-10（IL-10）水平降低。TBI 后使用 OMSCs 可降低心脏和肾脏中这些因素的变化。

结论

TBI 后应用 OMSCs 可减轻心脏和肾脏组织的炎症和氧化应激，从而减少损伤。因此，在未来的研究中可以在 TBI 患者中评估这种方法。

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