血清 CEACAM1 水平在非小细胞肺癌患者中的变化及其在癌组织中的临床意义。
Serum Level of CEACAM1 in Patients with Nonsmall Cell Lung Cancer and Its Clinical Significance in Cancer Tissue.
机构信息
Department of Clinical Laboratory, Ruijin People's Hospital of Jiangxi Province, Ruijin 342500, Jiangxi, China.
出版信息
J Healthc Eng. 2022 Apr 12;2022:7948010. doi: 10.1155/2022/7948010. eCollection 2022.
OBJECTIVE
To analyze the expression of CEACAM1 in serum of patients with nonsmall cell lung cancer (NSCLC) and to explore the correlation and clinical significance between the expression of CEACAM1 and pathological parameters of NSCLC tissue.
METHODS
A total of 100 patients with NSCLC who underwent tumor resection were screened. Another 100 healthy patients in physical examination department were selected as control group. Venous blood and cancer tissue samples were collected. The expression of CEACAM1, TGF-, VEGF-A, and IL-8 was detected.
RESULTS
The results of various indicators in the lung cancer group were much higher than those in the healthy group; CEACAM1 was significantly positively correlated with TGF- expression. The later the clinical stage and the higher the degree of differentiation of cancer tissue specimens, the more the expression of CEACAM1 in serum samples.
CONCLUSIONS
The expression level of CEACAM1 in the serum of NSCLC patients is strongly correlated with TGF-, VEGF-A, and IL-8, indicating that serum CEACAM1 and TGF- levels can predict the occurrence, progression, and prognosis of lung cancer and provide a target for future targeted therapy of lung cancer.
目的
分析非小细胞肺癌（NSCLC）患者血清中 CEACAM1 的表达，探讨 CEACAM1 的表达与 NSCLC 组织病理参数之间的相关性及其临床意义。
方法
筛选 100 例接受肿瘤切除术的 NSCLC 患者作为观察组，另选同期体检健康者 100 例作为对照组。采集静脉血和癌组织标本，检测 CEACAM1、TGF-β、VEGF-A 和 IL-8 的表达。
结果
肺癌组各项指标结果均明显高于对照组；CEACAM1 与 TGF-β表达呈显著正相关。临床分期越晚、癌组织标本分化程度越低，血清样本中 CEACAM1 的表达越高。
结论
NSCLC 患者血清中 CEACAM1 的表达水平与 TGF-β、VEGF-A 和 IL-8 呈强相关，提示血清 CEACAM1 和 TGF-β水平可预测肺癌的发生、进展和预后，为肺癌的靶向治疗提供了靶点。
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