CEACAM1 的结构与功能在免疫中的作用及其治疗意义。
CEACAM1 structure and function in immunity and its therapeutic implications.
机构信息
Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
出版信息
Semin Immunol. 2019 Apr;42:101296. doi: 10.1016/j.smim.2019.101296.
The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed in the tumor environment and is strictly regulated on lymphocytes such that its expression is restricted to activated cells where it is now recognized to function in tolerance pathways. CEACAM1 is also an important target for microbes which have co-opted these attributes of CEACAM1 for the purposes of invading the host and evading the immune system. These properties, among others, have focused attention on CEACAM1 as a unique target for immunotherapy in autoimmunity and cancer. This review examines recent structural information derived from the characterization of CEACAM1:CEACAM1 interactions and heterophilic modes of binding especially to microbes and how this relates to CEACAM1 function. Through this, we aim to provide insights into targeting CEACAM1 for therapeutic intervention.
I 型膜蛋白受体癌胚抗原相关细胞黏附分子 1（CEACAM1）表现出明显的选择性剪接，使其在同亲结合时具有可调的功能。CEACAM1 在肿瘤微环境中高度表达，并在淋巴细胞上受到严格调控，其表达仅限于激活的细胞，在这些细胞中，它被认为在耐受途径中发挥作用。CEACAM1 也是微生物的重要靶标，微生物已经利用了 CEACAM1 的这些特性来入侵宿主并逃避免疫系统。这些特性使 CEACAM1 成为自身免疫和癌症免疫治疗的独特靶标，引起了广泛关注。本综述考察了最近从 CEACAM1 的特性中获得的结构信息：CEACAM1 相互作用和同种型结合的异亲模式，特别是与微生物的结合方式，以及这与 CEACAM1 功能的关系。通过这些，我们旨在为针对 CEACAM1 的治疗干预提供深入了解。
Zotero 插件