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基于铪的金属有机框架纳米颗粒作为放射增敏剂以提高食管癌放疗疗效

Hafnium-Based Metal-Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer.

作者信息

Zhou Wei, Liu Zhulong, Wang Nana, Chen Xue, Sun Xiaozheng, Cheng Yufeng

机构信息

Department of Radiation Oncology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan 250100, China.

出版信息

ACS Omega. 2022 Mar 30;7(14):12021-12029. doi: 10.1021/acsomega.2c00223. eCollection 2022 Apr 12.

DOI:10.1021/acsomega.2c00223
PMID:35449918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9016869/
Abstract

Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at the tumor site. The use of radiosensitizers containing high elements is an effective way to enhance X-ray absorption. Here, we demonstrate a simple one-step method for the synthesis of UiO-66-NH(Hf) metal-organic framework nanoparticles for use as radiosensitizers in radiotherapy. The UiO-66-NH(Hf) nanoparticles had a diameter of less than 100 nm and were stable in the physiological environment. UiO-66-NH(Hf) induced apoptosis by enhancing X-ray absorption, as confirmed by and experiments. These characteristics make UiO-66-NH(Hf) a promising radiosensitizer for esophageal cancer radiotherapy.

摘要

放射疗法是肿瘤临床治疗中应用最为广泛的方法之一，但它存在局限性，比如在肿瘤部位的X射线滞留效果不佳。使用含高原子序数元素的放射增敏剂是增强X射线吸收的有效途径。在此，我们展示了一种简单的一步法来合成UiO-66-NH(Hf)金属有机框架纳米粒子，用作放射疗法中的放射增敏剂。UiO-66-NH(Hf)纳米粒子直径小于100纳米，在生理环境中稳定。通过[具体实验1]和[具体实验2]实验证实，UiO-66-NH(Hf)通过增强X射线吸收诱导细胞凋亡。这些特性使UiO-66-NH(Hf)成为一种有前景的用于食管癌放射治疗的放射增敏剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/8894e42935ac/ao2c00223_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/aec05ad67b33/ao2c00223_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/7e18757cf257/ao2c00223_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/ff1c3bec68ee/ao2c00223_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/aee8617bf9c8/ao2c00223_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/12f13ac1b4e1/ao2c00223_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/8894e42935ac/ao2c00223_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/aec05ad67b33/ao2c00223_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/7e18757cf257/ao2c00223_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/ff1c3bec68ee/ao2c00223_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/aee8617bf9c8/ao2c00223_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/12f13ac1b4e1/ao2c00223_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d248/9016869/8894e42935ac/ao2c00223_0006.jpg

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[3]
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Coord Chem Rev. 2025-7-15

[4]
Global trends and emerging research in nanotechnology for esophageal cancer: a comprehensive bibliometric analysis.

Discov Oncol. 2025-3-3

[5]
Catalytically Active Ti-Based Nanomaterials for Hydroxyl Radical Mediated Clinical X-Ray Enhancement.

Adv Sci (Weinh). 2024-12

[6]
Biomimetic Gd-Metal-Organic Framework Radiosensitizer for Near-Infrared Fluorescence Imaging-Guided Radiotherapy toward Nasopharyngeal Carcinoma.

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[7]
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Asian J Pharm Sci. 2024-4

[8]
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[9]
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[10]
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本文引用的文献

[1]
Neodymium (3+)-Coordinated Black Phosphorus Quantum Dots with Retrievable NIR/X-Ray Optoelectronic Switching Effect for Anti-Glioblastoma.

Small. 2022-2

[2]
Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer.

Nat Rev Clin Oncol. 2022-2

[3]
Piezo-Photocatalysis over Metal-Organic Frameworks: Promoting Photocatalytic Activity by Piezoelectric Effect.

Adv Mater. 2021-12

[4]
Structural diversity of nanoscale zirconium porphyrin MOFs and their photoactivities and biological performances.

J Mater Chem B. 2021-9-29

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Biomimetic nanoscale metal-organic framework harnesses hypoxia for effective cancer radiotherapy and immunotherapy.

Chem Sci. 2020-4-20

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Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer.

Adv Mater. 2021-6

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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.

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Nanotechnology for modern medicine: next step towards clinical translation.

J Intern Med. 2021-9

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Metal-organic frameworks: a future toolbox for biomedicine?

Chem Soc Rev. 2020-12-21

[10]
Organelle-localized radiosensitizers.

Chem Commun (Camb). 2020-9-15

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