与雄性猫尿道梗阻解除后严重梗阻后利尿发展相关的表现变量。
Presentation Variables Associated With the Development of Severe Post-obstructive Diuresis in Male Cats Following Relief of Urethral Obstruction.
作者信息
Muller Kelly M, Burkitt-Creedon Jamie M, Epstein Steven E
机构信息
School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
出版信息
Front Vet Sci. 2022 Apr 5;9:783874. doi: 10.3389/fvets.2022.783874. eCollection 2022.
BACKGROUND
Diuresis following relief of urethral obstruction is a potentially life-threatening complication of feline urethral obstruction. Evidence regarding the incidence of post-obstructive diuresis (POD) in cats is scarce. Establishing historical, physical examination, and initial clinicopathologic variables associated with risk for developing POD may better enable clinicians to direct treatment for this common feline emergency and to educate clients regarding financial expectations.
OBJECTIVES
To report the incidence of POD in a large group of cats with urethral obstruction and determine whether select presenting physical examination or initial clinicopathologic variables may predict the onset or severity of POD.
METHODS
The records of 260 cats that were admitted to the University of California, Davis, Veterinary Medical Teaching Hospital for urethral obstruction were reviewed. Urine output after urethral catherization was categorized into no POD (urine output ≤ 2 mL/kg/h), mild-moderate POD (urine output > 2 but <5 mL/kg/h) and severe POD (urine output ≥ 5 mL/kg/h). Select presentation physical examination, venous acid-base, electrolyte, serum biochemistry, and urinalysis results were compared among the groups.
RESULTS
67.7% of cats experienced POD, and in 35% of cats it was categorized as severe. Evaluated historical and physical examination variables correlated with development of POD were lower body weight and, for severe POD, hypovolemia. Clinicopathologic variables associated with development of POD included acidemia, azotemia, hyperphosphatemia, hyperkalemia, hyponatremia, hypochloremia, hypocalcemia, hypermagnesemia, and hypoalbuminemia. Cats with severe POD were hospitalized a median of 1 day longer than those without POD.
CONCLUSIONS
Results of the present study indicate that there are presentation variables associated with onset and severity of POD following relief of feline urethral obstruction.
背景
尿道梗阻解除后的利尿是猫尿道梗阻一种潜在的危及生命的并发症。关于猫梗阻后利尿（POD）发生率的证据很少。确定与发生POD风险相关的病史、体格检查及初始临床病理变量，可能会使临床医生更好地指导这种常见猫科急症的治疗，并就费用预期对客户进行教育。
目的
报告一大组尿道梗阻猫的POD发生率，并确定某些呈现的体格检查或初始临床病理变量是否可预测POD的发生或严重程度。
方法
回顾了260只因尿道梗阻入住加利福尼亚大学戴维斯分校兽医医学教学医院的猫的记录。尿道插管后的尿量分为无POD（尿量≤2 mL/kg/h）、轻至中度POD（尿量>2但<5 mL/kg/h）和重度POD（尿量≥5 mL/kg/h）。比较各组呈现的体格检查、静脉酸碱、电解质、血清生化及尿液分析结果。
结果
67.7%的猫发生了POD，其中35%被归类为重度。与POD发生相关的评估病史和体格检查变量为体重较低，对于重度POD为血容量不足。与POD发生相关的临床病理变量包括酸血症、氮质血症、高磷血症、高钾血症、低钠血症、低氯血症、低钙血症、高镁血症和低白蛋白血症。重度POD的猫住院时间中位数比无POD的猫长1天。
结论
本研究结果表明，猫尿道梗阻解除后存在与POD发生及严重程度相关的呈现变量。
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