Chin Edwin C, Yu Angus P, Leung Chit K, Bernal Joshua D, Au Whitney W, Fong Daniel Y, Cheng Calvin P, Siu Parco M
Division of Kinesiology, School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
School of Nursing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Front Physiol. 2022 Apr 5;13:863457. doi: 10.3389/fphys.2022.863457. eCollection 2022.
The effects of exercise frequency and intensity on alleviating depressive symptoms in older adults with insomnia are unclear.
The purpose of this study was to investigate the influence of different exercise frequencies and intensities on prescribed aerobic-type physical activity (i.e., 75 min of vigorous-intensity exercise or 150 min of moderate-intensity exercise weekly) for reducing depressive symptoms in older adults living with insomnia, as recommended by the WHO.
This study is a randomized, controlled, assessor-blinded trial.
This study is conducted at a single research site in Hong Kong.
This study includes older adults aged 50 years or above with depressive symptoms and insomnia.
Participants were randomly assigned in a 1:1:1:1:1 ratio to the following groups: attention control (CON), moderate walking once weekly (MOD × 1/week), moderate walking thrice weekly (MOD × 3/week), vigorous walking once weekly (VIG × 1/week), and vigorous walking thrice weekly (VIG × 3/week). The total weekly exercise volumes among the walking groups were matched to the minimum recommended physical activity volume.
Depression, anxiety, self-perceived sleep quality, insomnia severity, actigraphy-assessed 7-day sleep data, 7-day sleep diary, cardiorespiratory fitness, adherence, and habitual physical activity were examined at baseline and after 12 weeks of intervention.
Both MOD × 3/week and VIG × 3/week groups demonstrated reduced depression (Hospital Anxiety and Depression Scale [HADS] - Depression: MOD × 3/wk: -68.6%; VIG × 3/week: -67.4%) and anxiety levels (HADS - Anxiety: MOD × 3/week: -54.3%; VIG × 3/week: -59.8%) compared with CON (both < 0.01). Self-perceived sleep quality was improved in MOD × 3/week (-31.4% of the Pittsburgh Sleep Quality Index [PSQI]), VIG × 1/week (-34.1% of PSQI), and VIG × 3/week (-38.3% of PSQI), but not in MOD × 1/week, when compared with CON ( < 0.05). No serious adverse events were observed in this study.
The effects of walking training on reducing depressive symptoms appeared to be dependent on exercise frequency. Our findings suggest that three sessions of walking per week at either moderate or vigorous-intensity effectively alleviate depressive symptoms in older adults with insomnia. Additional research is needed to further verify the effects of exercise frequency on depression.
[ClinicalTrials.gov], identifier [NCT04354922].
运动频率和强度对缓解失眠老年人抑郁症状的影响尚不清楚。
本研究旨在探讨不同运动频率和强度对按照世界卫生组织建议进行的规定有氧型体育活动（即每周75分钟的高强度运动或150分钟的中等强度运动）在减轻失眠老年患者抑郁症状方面的影响。
本研究是一项随机、对照、评估者盲法试验。
本研究在香港的一个单一研究地点进行。
本研究纳入年龄在50岁及以上、有抑郁症状和失眠的老年人。
参与者按1:1:1:1:1的比例随机分配到以下组：注意力控制组（CON）、每周一次中等强度步行组（MOD×1/周）、每周三次中等强度步行组（MOD×3/周）、每周一次高强度步行组（VIG×1/周）和每周三次高强度步行组（VIG×3/周）。步行组的每周总运动量与建议的最低体育活动量相匹配。
在基线和干预12周后，对抑郁、焦虑、自我感知睡眠质量、失眠严重程度、活动记录仪评估的7天睡眠数据、7天睡眠日记、心肺适能、依从性和习惯性身体活动进行检查。
与CON组相比，MOD×3/周组和VIG×3/周组的抑郁（医院焦虑抑郁量表[HADS]-抑郁：MOD×3/周组：-68.6%；VIG×3/周组：-67.4%）和焦虑水平（HADS-焦虑：MOD×3/周组：-54.3%；VIG×3/周组：-59.8%）均降低（均P<0.01）。与CON组相比，MOD×3/周组（匹兹堡睡眠质量指数[PSQI]降低31.4%）、VIG×1/周组（PSQI降低34.1%）和VIG×3/周组（PSQI降低38.3%）的自我感知睡眠质量得到改善，但MOD×1/周组未改善（P<0.05）。本研究未观察到严重不良事件。
步行训练对减轻抑郁症状的效果似乎取决于运动频率。我们的研究结果表明，每周进行三次中等强度或高强度步行可有效缓解失眠老年人的抑郁症状。需要进一步的研究来进一步验证运动频率对抑郁的影响。
[ClinicalTrials.gov]，标识符[NCT04354922]。
