2 型糖尿病患者皮肤晚期糖基化终产物与心脏自主神经病变的相关性。

Correlation Between Skin Advanced Glycation End Products and Cardiac Autonomic Neuropathy Among Subjects with Type 2 Diabetes Mellitus.

机构信息

Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece.

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

出版信息

Exp Clin Endocrinol Diabetes. 2022 Dec;130(12):767-772. doi: 10.1055/a-1831-0991. Epub 2022 Apr 21.

DOI:10.1055/a-1831-0991

PMID:35451045

Abstract

INTRODUCTION

Advanced glycation end products (AGEs) are frequently increased in the skin of subjects with type 2 diabetes mellitus (T2DM). This study aimed to examine the correlation of AGEs with cardiac autonomic neuropathy (CAN) in T2DM.

METHODS

To this aim, 132 participants (88 men) with a mean age of 64.57 years and a median T2DM duration of 14.5 years were included. Skin AGEs were measured with AGE reader mu connect (Diagnoptics) on the dominant arm (both single and automated triplicate measurements). Diagnosis of CAN, sympathetic and parasympathetic nervous system impairment was based on the four standardised cardiovascular reflex tests (CARTs).

RESULTS

On a single measurement, AGEs were increased in subjects with vs. those without CAN (3.20±0.74 vs. 2.66±0.66, p<0.001). As compared with normal results, AGEs were increased for each one of the 4 abnormal CARTs: Valsalva Ratio (3.36±0.67 vs. 2.66±0.72, p=0.004), E/I ratio (3.01±0.72 vs. 2.53±0.68, p=0.001), 30:15 ratio (3.08±0.76 vs. 2.75±0.69, p=0.011), postural hypotension (3.30±0.72 vs. 2.75±0.66, p<0.001). Similar results were obtained for triplicate measurements.

DISCUSSION

Among T2DM subjects, skin AGEs appear to increase in the presence of CAN. This holds true both for sympathetic and parasympathetic nervous system impairment.

摘要

简介

糖化终产物（AGEs）在 2 型糖尿病（T2DM）患者的皮肤中经常升高。本研究旨在探讨 T2DM 患者 AGEs 与心脏自主神经病变（CAN）的相关性。

方法

为此，纳入了 132 名参与者（88 名男性），平均年龄为 64.57 岁，中位 T2DM 病程为 14.5 年。在优势手臂上使用 AGE 阅读器 mu connect（Diagnoptics）测量皮肤 AGEs（单次和自动化重复测量）。根据四项标准化心血管反射测试（CARTs）诊断 CAN 和交感神经和副交感神经系统损伤。

结果

在单次测量中，有 CAN 的患者的 AGEs 高于无 CAN 的患者（3.20±0.74 对 2.66±0.66，p<0.001）。与正常结果相比，4 项异常 CART 中的每一项 AGEs 均增加：瓦尔萨尔瓦比值（3.36±0.67 对 2.66±0.72，p=0.004），E/I 比值（3.01±0.72 对 2.53±0.68，p=0.001），30:15 比值（3.08±0.76 对 2.75±0.69，p=0.011），体位性低血压（3.30±0.72 对 2.75±0.66，p<0.001）。重复测量也得到了类似的结果。