大麻使用与牙周炎风险：两样本孟德尔随机化研究。

Cannabis use and the risk of periodontitis: A two-sample Mendelian randomization study.

机构信息

Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany.

Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

出版信息

J Clin Periodontol. 2022 Jul;49(7):654-661. doi: 10.1111/jcpe.13632. Epub 2022 May 3.

DOI:10.1111/jcpe.13632

PMID:35451161

Abstract

AIM

This study aimed to leverage human genetic data to investigate whether cannabis use causally affects periodontitis.

MATERIALS AND METHODS

Data were obtained from summary statistics of genome-wide association studies of lifetime cannabis use (N = 184,765), cannabis use disorder (17,068 cases; 357,219 controls), and periodontitis (17,353 cases; 28,210 controls). We performed two-sample Mendelian randomization (MR) analysis using 6 genetic variants as instrumental variables for lifetime cannabis use and 11 variants as instruments for cannabis use disorder to estimate associations with periodontitis.

RESULTS

There was no evidence for an association between genetic liability for lifetime cannabis use or cannabis use disorder with periodontitis. The estimates from the primary analyses were supported in multivariable MR analysis, which considered potential pleiotropic pathways and in weak instrument analyses.

CONCLUSIONS

This study provides little evidence to support a detrimental effect of genetic liability for cannabis use on periodontal health.

摘要

目的

本研究旨在利用人类遗传数据来探究大麻使用是否会对牙周炎产生因果影响。

材料和方法

本研究的数据来源于终生大麻使用（N=184765）、大麻使用障碍（病例 17068 例，对照 357219 例）和牙周炎（病例 17353 例，对照 28210 例）的全基因组关联研究的汇总统计数据。我们使用 6 个遗传变异作为终生大麻使用的工具变量，11 个变异作为大麻使用障碍的工具变量，进行两样本 Mendelian 随机化（MR）分析，以评估与牙周炎的关联。