Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany.
Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
J Clin Periodontol. 2022 Jul;49(7):654-661. doi: 10.1111/jcpe.13632. Epub 2022 May 3.
This study aimed to leverage human genetic data to investigate whether cannabis use causally affects periodontitis.
Data were obtained from summary statistics of genome-wide association studies of lifetime cannabis use (N = 184,765), cannabis use disorder (17,068 cases; 357,219 controls), and periodontitis (17,353 cases; 28,210 controls). We performed two-sample Mendelian randomization (MR) analysis using 6 genetic variants as instrumental variables for lifetime cannabis use and 11 variants as instruments for cannabis use disorder to estimate associations with periodontitis.
There was no evidence for an association between genetic liability for lifetime cannabis use or cannabis use disorder with periodontitis. The estimates from the primary analyses were supported in multivariable MR analysis, which considered potential pleiotropic pathways and in weak instrument analyses.
This study provides little evidence to support a detrimental effect of genetic liability for cannabis use on periodontal health.
本研究旨在利用人类遗传数据来探究大麻使用是否会对牙周炎产生因果影响。
本研究的数据来源于终生大麻使用（N=184765）、大麻使用障碍（病例 17068 例，对照 357219 例）和牙周炎（病例 17353 例，对照 28210 例）的全基因组关联研究的汇总统计数据。我们使用 6 个遗传变异作为终生大麻使用的工具变量，11 个变异作为大麻使用障碍的工具变量，进行两样本 Mendelian 随机化（MR）分析，以评估与牙周炎的关联。
遗传易感性与终生大麻使用或大麻使用障碍与牙周炎之间没有关联的证据。主要分析的结果在多变量 MR 分析中得到了支持，该分析考虑了潜在的多效性途径和弱工具分析。
本研究几乎没有提供证据支持大麻使用的遗传易感性对牙周健康的不利影响。
