Imshenetskaia V F
Antibiotiki. 1978 Jul;23(7):644-7.
The data on tetracycline penetration from the blood into the serebrospinal fluid of patients with different diseases of the central nervous system are presented. Clinico-laboratory comparisons showed that the antibiotic penetration did not depend on the character and severity of the main disease of the brain (tumor, trauma, abscess). No dependence on the surgical intervention was either found. The index of tetracycline penetration from the blood into the liquor did not depend on the drug administration route, i.e. intramuscularly or orally. The presence of the post-operative meningitis increased permeability of the brain membranes for tetracycline.
本文展示了四环素从血液进入患有不同中枢神经系统疾病患者脑脊液的相关数据。临床实验室比较表明，抗生素的渗透并不取决于脑部主要疾病（肿瘤、创伤、脓肿）的性质和严重程度。也未发现其与手术干预有相关性。四环素从血液进入脑脊液的指标并不取决于给药途径，即肌肉注射或口服。术后脑膜炎的存在增加了四环素透过脑膜的通透性。
