Imshenetskaia V F
Antibiotiki. 1976 Aug;21(8):745-7.
Penetration of methicillin through the blood-liquor barrier in neurosurgical patients was studied. When administered in a dose of 2 gm the drug penetrated through the barrier in 1/3 of all observations within 1 to 3 hours. Increased liquor pressure in the patients resulted in prolongation of the antibiotic effect in the cerebrospinal fluid. The methicillin levels in the liquor were no sufficient for the growth inhibition of most methicillin sensitive staphylococci.
研究了甲氧西林在神经外科患者中透过血脑屏障的情况。当给予2克剂量时，在1至3小时内，所有观察病例中有1/3的药物透过了屏障。患者脑脊液压力升高导致抗生素在脑脊液中的作用时间延长。脑脊液中甲氧西林的水平不足以抑制大多数对甲氧西林敏感的葡萄球菌的生长。
