Imshenetskaia V F
Antibiotiki. 1977 Apr;22(4):367-71.
Penetration of oleandomycin into the subarachnoid space in neurosurgical patients treated with the drug administered orally and intramuscularly in doses of 375 and 500 mg respectively was studied. The oleandomycin levels in the blood and cerobrospinal fluid were determined after a single administration of the antibiotic at an interval of 30 minutes to 7 hours. A total of 52 observations were recorded. Relation between oleandomycin penetration into the cerebrospinal fluid from the blood and the administration route was shown. The index of penetration through the blood-liquor barrier for the antibiotic intramuscular or oral administration was 9--70 and 3--40 per cent respectively. The maximum concentrations of the drug in the liquor were found in the patients with the clinical picture of meningitis.
研究了在神经外科患者中，分别以375毫克和500毫克的剂量口服和肌肉注射竹桃霉素时，该药物进入蛛网膜下腔的情况。在单次给予抗生素后，每隔30分钟至7小时测定血液和脑脊液中的竹桃霉素水平。共记录了52次观察结果。结果显示了竹桃霉素从血液进入脑脊液的渗透情况与给药途径之间的关系。肌肉注射或口服该抗生素时，其透过血脑屏障的渗透指数分别为9% - 70%和3% - 40%。在患有脑膜炎临床表现的患者中发现脑脊液中该药物的最高浓度。
