Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of São Paulo, São Paulo, Brazil.
J Neural Transm (Vienna). 2022 Jun;129(5-6):611-615. doi: 10.1007/s00702-022-02496-3. Epub 2022 Apr 22.
More than 100 years after its conceptual definition as 'Dementia Praecox' by Emil Kraepelin, which was changed to schizophrenia by Eugen Bleuler, this is still a serious and debilitating psychiatric illness. The neurodevelopmental hypothesis of schizophrenia, introduced more than 30 years ago, states that schizophrenia is a consequence of failed neurodevelopmental processes leading to a dysfunctional neuronal network forming the basis for a psychosis proneness. Subsequently, significant research efforts were made to prove the neurodevelopmental or the neurodegenerative perspective. This review summarizes key arguments speaking for or against the two hypotheses leading to a concept with both aspects position side by side.
在埃米尔·克雷佩林（Emil Kraepelin）将其概念定义为“早发性痴呆”（Dementia Praecox）并由 Eugen Bleuler 更改为精神分裂症 100 多年后，它仍然是一种严重且使人虚弱的精神疾病。精神分裂症的神经发育假说早在 30 多年前就已提出，该假说指出，精神分裂症是神经发育过程失败的结果，导致功能失调的神经网络形成易患精神病的基础。随后，人们进行了大量研究工作来证明神经发育或神经退行性的观点。这篇综述总结了支持或反对这两个假说的关键论点，从而形成了一个同时具有这两个方面的概念。
