Department of Robotics and Mechatronics, University of Twente, Hallenweg 15, Enschede, Overijssel, 7500 NH, The Netherlands.
Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, Nijmegen, Gelderland, 6525 GA, The Netherlands.
Int J Comput Assist Radiol Surg. 2022 Aug;17(8):1399-1407. doi: 10.1007/s11548-022-02618-y. Epub 2022 Apr 22.
In recent years, irreversible electroporation (IRE) has been developed to specifically destroy undesirable tissues as an alternative to surgical resection. In this treatment, placing multiple electrodes in parallel is required to create a uniform electric field distribution. The process of maintaining parallel electrodes is challenging, and the effect of the electrodes' orientation accuracy has not been investigated quantitatively. This study investigates the impact of the electrode orientation along with various electrode and pulse parameters on the outcomes of IRE.
The electrode configurations that were considered were parallel, forward, and sideward orientation. A numerical model was developed to study the effect of electrode orientation on the electric field distribution, which was validated experimentally on potato tubers as it has similar properties to biological tissue. In addition, a conductivity test was performed to evaluate the conductivity and electroporation threshold of the potatoes.
The developed numerical model was validated by comparing the electroporated volumes between potatoes from the experiment and simulation, which achieved a mean dice score of [Formula: see text]. The potato has an electrical conductivity of 0.044-0.454 S/m with an electroporation threshold of 375 V/cm. ANOVA test showed that the difference in the electroporated regions obtained between a parallel orientation and a 5[Formula: see text] forward and sideward orientation was not significant.
This study showed that the developed numerical models were validated and able to predict the outcome of IRE on potatoes. In addition, a 5[Formula: see text] tolerance on the electrode orientation can be defined to obtain a similar response to the parallel orientation.
近年来，不可逆电穿孔（IRE）已被开发出来，作为手术切除的替代方法，专门破坏不需要的组织。在这种治疗中，需要放置多个平行电极以创建均匀的电场分布。保持平行电极的过程具有挑战性，并且尚未对电极取向精度的效果进行定量研究。本研究调查了电极取向以及各种电极和脉冲参数对 IRE 结果的影响。
考虑的电极配置为平行、正向和侧向取向。开发了一个数值模型来研究电极取向对电场分布的影响，并在马铃薯块茎上进行了实验验证，因为马铃薯块茎具有与生物组织相似的特性。此外，还进行了电导率测试以评估马铃薯的电导率和电穿孔阈值。
通过将来自实验和模拟的马铃薯的电穿孔体积进行比较，验证了所开发的数值模型，平均骰子得分达到[公式：见文本]。马铃薯的电导率为 0.044-0.454 S/m，电穿孔阈值为 375 V/cm。方差分析测试表明，在平行取向和 5[公式：见文本]正向和侧向取向之间获得的电穿孔区域之间的差异不显著。
本研究表明，所开发的数值模型已得到验证，能够预测马铃薯上 IRE 的结果。此外，可以定义 5[公式：见文本]的电极取向容差，以获得与平行取向相似的响应。
