INRIA Bordeaux-Sud-Ouest, CNRS, Bordeaux INP, Univ. Bordeaux, IMB, UMR 5251, F-33400, Talence, France.
Phys Med Biol. 2019 Mar 7;64(5):055016. doi: 10.1088/1361-6560/ab00c4.
The paper provides a numerical workflow, based on the 'real-life' clinical workflow of irreversible electroporation (IRE) performed for the treatment of deep-seated liver tumors. Thanks to a combination of numerical modeling, image registration algorithm and clinical data, our numerical workflow enables to provide the distribution of the electric field as effectively delivered by the clinical IRE procedure. As a proof of concept, we show on a specific clinical case of IRE ablation of liver tumor that clinical data could be advantageously combined to numerical simulations in a near future, in order to give to the interventional radiologists information on the effective IRE ablation. We also corroborate the simulated treated region with the post-treatment MRI performed 3 d after the treatment.
本文提供了一个数值工作流程，该流程基于不可逆电穿孔（IRE）治疗深部肝脏肿瘤的“实际”临床工作流程。得益于数值建模、图像配准算法和临床数据的结合，我们的数值工作流程能够提供临床 IRE 手术有效传递的电场分布。作为概念验证，我们展示了一个特定的 IRE 消融肝脏肿瘤的临床病例，表明在不久的将来，临床数据可以与数值模拟相结合，以便为介入放射科医生提供关于有效 IRE 消融的信息。我们还通过治疗后 3 天进行的 MRI 检查来验证模拟治疗区域。
