Li Qilin, Xu Rengui, Fan Huiling, Xu Jiarong, Xu Yunruo, Cao Peng, Zhang Yan, Liang Tao, Zhang Yang, Chen Wei, Wang Zheng, Wang Lin, Chen Xiaoyuan
Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China.
ACS Nano. 2022 May 24;16(5):7512-7524. doi: 10.1021/acsnano.1c10718. Epub 2022 Apr 22.
The key to controlling the spread of the coronavirus disease 2019 (COVID-19) and reducing mortality is highly dependent on the safe and effective use of vaccines for the general population. Current COVID-19 vaccination practices (intramuscular injection of solution-based vaccines) are limited by heavy reliance on medical professionals, poor compliance, and laborious vaccination recording procedures, resulting in a waste of health resources and low vaccination coverage, In this study, we developed a smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle platform for the effective and convenient delivery of multidose COVID-19 vaccines and decentralized vaccine information storage. The mushroom-like structure allows the MILD system to be easily pressed into the skin and detached from the patch base, acting as a "tattoo" to record the vaccine counts without any storage equipment, offering quick accessibility and effortless readout, saving a great deal of valuable time and energy for both patients and health professionals. After loading inactivated SARS-CoV-2 virus-based vaccines, MILD system induced a high level of antibodies against the SARS-CoV-2 receptor-binding domain (RBD) without eliciting systemic toxicity and local damage. Collectively, this smart delivery platform serves as a promising carrier to improve COVID-19 vaccination efficacy through its dual capabilities of vaccine delivery and data storage, thus exhibiting great potential for helping to contain the COVID-19 pandemic or a resurgence.
控制2019冠状病毒病（COVID-19）传播和降低死亡率的关键高度依赖于普通人群安全有效地使用疫苗。当前的COVID-19疫苗接种做法（肌肉注射基于溶液的疫苗）受到严重依赖医疗专业人员、依从性差和繁琐的接种记录程序的限制，导致卫生资源浪费和疫苗接种覆盖率低。在本研究中，我们开发了一种受蘑菇启发的可打印且易于拆卸的智能微针平台（MILD），用于有效且便捷地递送多剂量COVID-19疫苗以及分散式疫苗信息存储。蘑菇状结构使MILD系统能够轻松压入皮肤并从贴片底座分离，充当记录疫苗接种次数的“纹身”，无需任何存储设备，提供快速的可及性和轻松的读取方式，为患者和卫生专业人员节省大量宝贵的时间和精力。在装载基于灭活严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒的疫苗后，MILD系统诱导产生了高水平的针对SARS-CoV-2受体结合域（RBD）的抗体，且未引发全身毒性和局部损伤。总体而言，这个智能递送平台作为一种有前景的载体，通过其疫苗递送和数据存储的双重能力提高COVID-19疫苗接种效果，因此在帮助控制COVID-19大流行或疫情复发方面展现出巨大潜力。
