心肌梗死患者中适合溶栓治疗的比例是多少？
What proportion of patients with myocardial infarction are suitable for thrombolysis?
作者信息
Murray N, Lyons J, Layton C, Balcon R
出版信息
Br Heart J. 1987 Feb;57(2):144-7. doi: 10.1136/hrt.57.2.144.
Abstract
Four hundred and three patients were considered for entry into a trial of intravenous streptokinase in suspected myocardial infarction. Three hundred and sixty seven (91%) were excluded. Two hundred and sixty (65%) did not meet the inclusion criteria and 45 of the remaining 143 (35%) patients had contraindications to thrombolysis. This left 98 (24%) patients who were suitable for thrombolysis and 42 of them were over 70 years, the upper age limit. Thus according to this trial protocol 56 (14%) patients were eligible for recruitment; 36 (9%) patients were finally randomised. These data suggest that treatment with intravenous streptokinase may be applicable to only a small proportion of patients with myocardial infarction.
摘要
403名患者被考虑纳入疑似心肌梗死静脉注射链激酶的试验。367名（91%）被排除。260名（65%）不符合纳入标准，其余143名患者中有45名（35%）有溶栓禁忌症。这使得98名（24%）患者适合溶栓，其中42名年龄超过70岁这一年龄上限。因此，根据该试验方案，56名（14%）患者符合招募条件；最终36名（9%）患者被随机分组。这些数据表明，静脉注射链激酶治疗可能仅适用于一小部分心肌梗死患者。
相似文献
1
What proportion of patients with myocardial infarction are suitable for thrombolysis?心肌梗死患者中适合溶栓治疗的比例是多少？
Br Heart J. 1987 Feb;57(2):144-7. doi: 10.1136/hrt.57.2.144.
2
Long term improvement in global left ventricular function after early thrombolytic treatment in acute myocardial infarction. Report of a randomised multicentre trial of intracoronary streptokinase in acute myocardial infarction.急性心肌梗死早期溶栓治疗后左心室整体功能的长期改善。急性心肌梗死冠状动脉内链激酶随机多中心试验报告。
Br Heart J. 1986 Nov;56(5):414-21. doi: 10.1136/hrt.56.5.414.
3
Streptokinase in acute myocardial infarction: western Washington randomized trial--protocol and progress report.链激酶治疗急性心肌梗死：华盛顿州西部随机试验——方案与进展报告
Am Heart J. 1982 Oct;104(4 Pt 2):899-911. doi: 10.1016/0002-8703(82)90263-0.
4
Eligibility for streptokinase thrombolysis during evolving acute myocardial infarction. An historical cohort study.急性心肌梗死进展期链激酶溶栓治疗的适应证。一项历史性队列研究。
Fam Pract Res J. 1986 Spring;5(3):177-89.
5
Thrombolysis, streptokinase, and TPA in the treatment of acute myocardial infarction.
Cardiovasc Clin. 1987;18(1):247-57.
6
The thrombolysis in myocardial infarction (TIMI) trial phase I and phase IIA pilot results. Implications for nursing.心肌梗死溶栓治疗（TIMI）试验第一阶段和第二阶段A期初步结果。对护理工作的启示。
Prog Cardiovasc Nurs. 1988 Oct-Dec;3(4):128-36.
7
Myocardial surgical revascularization after streptokinase treatment for acute myocardial infarction.链激酶治疗急性心肌梗死后的心肌外科血管重建术。
J Thorac Cardiovasc Surg. 1985 Jan;89(1):25-34.
8
Intracoronary thrombolysis in patients with acute myocardial infarction: the Netherlands Randomized Trial and current status.急性心肌梗死患者的冠状动脉内溶栓治疗：荷兰随机试验及现状
Circulation. 1987 Aug;76(2 Pt 2):II63-78.
9
Streptokinase in acute myocardial infarction.急性心肌梗死中的链激酶
Acta Med Scand Suppl. 1981;648:1-117.
10
Cost benefit analysis of early thrombolytic treatment with intracoronary streptokinase. Twelve month follow up report of the randomised multicentre trial conducted by the Interuniversity Cardiology Institute of The Netherlands.冠状动脉内链激酶早期溶栓治疗的成本效益分析。荷兰大学间心脏病学研究所进行的随机多中心试验的12个月随访报告。
Br Heart J. 1988 May;59(5):527-34. doi: 10.1136/hrt.59.5.527.
引用本文的文献
1
Emergency primary coronary angioplasty in patients with acute myocardial infarction who are unsuitable for intravenous thrombolysis.
Ir J Med Sci. 1995 Oct-Dec;164(4):276-8. doi: 10.1007/BF02967203.
2
Availability of thrombolytic therapy in rural Newfoundland and Labrador.纽芬兰和拉布拉多农村地区溶栓治疗的可及性。
CMAJ. 1995 Jan 15;152(2):177-81.
3
Coronary thrombolysis.冠状动脉溶栓
Br Heart J. 1987 Apr;57(4):301-5. doi: 10.1136/hrt.57.4.301.
4
Early detection of acute myocardial infarction: additional diagnostic information from serum concentrations of myoglobin in patients without ST elevation.急性心肌梗死的早期检测：无ST段抬高患者血清肌红蛋白浓度提供的额外诊断信息
Br Heart J. 1990 Jun;63(6):335-8. doi: 10.1136/hrt.63.6.335.
本文引用的文献
1
Randomized comparison of intravenous versus intracoronary streptokinase for myocardial infarction.静脉注射与冠状动脉内注射链激酶治疗心肌梗死的随机对照研究。
Am J Cardiol. 1984 Jul 1;54(1):14-9. doi: 10.1016/0002-9149(84)90297-2.
2
Effects of intracoronary streptokinase and intracoronary nitroglycerin infusion on coronary angiographic patterns and mortality in patients with acute myocardial infarction.
N Engl J Med. 1984 Dec 6;311(23):1457-63. doi: 10.1056/NEJM198412063112301.
3
A randomized trial of intravenous and intracoronary streptokinase in patients with acute myocardial infarction.
Circulation. 1984 Oct;70(4):606-18. doi: 10.1161/01.cir.70.4.606.
4
Nifedipine therapy for patients with threatened and acute myocardial infarction: a randomized, double-blind, placebo-controlled comparison.硝苯地平治疗先兆及急性心肌梗死患者：一项随机、双盲、安慰剂对照比较研究。
Circulation. 1984 Apr;69(4):740-7. doi: 10.1161/01.cir.69.4.740.
5
Western Washington randomized trial of intracoronary streptokinase in acute myocardial infarction.西华盛顿州急性心肌梗死冠状动脉内链激酶随机试验。
N Engl J Med. 1983 Dec 15;309(24):1477-82. doi: 10.1056/NEJM198312153092402.
6
A randomized trial of intracoronary streptokinase in the treatment of acute myocardial infarction.
N Engl J Med. 1983 Jun 2;308(22):1312-8. doi: 10.1056/NEJM198306023082202.
7
Intracoronary fibrinolytic therapy in acute myocardial infarction. Report of a prospective randomized trial.
N Engl J Med. 1983 Jun 2;308(22):1305-11. doi: 10.1056/NEJM198306023082201.
8
Systemic versus intracoronary streptokinase infusion in the treatment of acute myocardial infarction.全身应用与冠状动脉内输注链激酶治疗急性心肌梗死的比较
J Am Coll Cardiol. 1983 May;1(5):1254-61. doi: 10.1016/s0735-1097(83)80137-5.
9
Lidocaine in the prevention of primary ventricular fibrillation. A double-blind, randomized study of 212 consecutive patients.
N Engl J Med. 1974 Dec 19;291(25):1324-6. doi: 10.1056/NEJM197412192912504.
10
Bleeding complications of intracoronary fibrinolytic therapy in acute myocardial infarction. Assessment of risk in a randomised trial.急性心肌梗死冠状动脉内溶栓治疗的出血并发症。一项随机试验中的风险评估。
Br Heart J. 1985 Nov;54(5):455-9. doi: 10.1136/hrt.54.5.455.
Zotero 插件