Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Drug Alcohol Depend. 2022 Jun 1;235:109458. doi: 10.1016/j.drugalcdep.2022.109458. Epub 2022 Apr 12.
Alcohol screening, brief intervention and referral to treatment (SBIRT) in adult primary care is an evidence-based, public health strategy to address unhealthy alcohol use, but evidence of effectiveness of alcohol brief intervention (ABI) in real-world implementation is lacking.
We fit marginal structural models with inverse probability weighting to estimate the causal effects of ABI on 12-month drinking outcomes using longitudinal electronic health records data for 312,056 adults with a positive screening result for unhealthy drinking between 2014 and 2017 in a large healthcare system that implemented systematic primary care-based SBIRT. We examined effects of ABI with and without adjusting for receipt of specialty alcohol use disorder (AUD) treatment, and whether effects varied by patient demographic characteristics and alcohol use patterns.
Receiving ABI resulted in significantly greater reductions in heavy drinking days (mean difference [95% CI] = -0.26 [-0.45, -0.08]), drinking days per week (-0.04 [-0.07, -0.01]), drinks per drinking day (-0.05 [-0.08, -0.02]) and drinks per week (-0.16 [-0.27, -0.04]). Effects of ABI on 12-month drinking outcomes varied by baseline consumption level, age group and whether patients already had an AUD, with better improvement in those who were drinking at levels exceeding only daily limits, younger, and without an AUD.
Systematic ABI in adult primary care has the potential to reduce drinking among people with unhealthy drinking considerably on both an individual and population level. More research is needed to help optimize ABI, in particular tailoring it to diverse sub-populations, and studying its long-term public health impact.
在成人初级保健中进行酒精筛查、简短干预和转介治疗(SBIRT)是一种基于证据的公共卫生策略,可用于解决不健康的饮酒问题,但在真实世界实施中,酒精简短干预(ABI)的有效性证据不足。
我们使用边际结构模型和逆概率加权来估计 ABI 对 12 个月饮酒结果的因果影响,使用纵向电子健康记录数据,这些数据来自 2014 年至 2017 年期间在一个实施系统的基于初级保健的 SBIRT 的大型医疗保健系统中,对有不健康饮酒阳性筛查结果的 312056 名成年人进行分析。我们检查了在调整和不调整接受专科酒精使用障碍(AUD)治疗的情况下,ABI 的效果,以及效果是否因患者人口统计学特征和饮酒模式而异。
接受 ABI 治疗与不接受 ABI 治疗相比,重度饮酒天数(平均差异[95%置信区间] = -0.26[-0.45,-0.08])、每周饮酒天数(-0.04[-0.07,-0.01])、每天饮酒量(-0.05[-0.08,-0.02])和每周饮酒量(-0.16[-0.27,-0.04])显著减少。ABI 对 12 个月饮酒结果的影响因基线饮酒水平、年龄组和患者是否已有 AUD 而异,在仅超过每日限量饮酒、年龄较小且无 AUD 的患者中,改善效果更好。
在成人初级保健中系统地进行 ABI 有可能在个人和人群层面上大大减少饮酒量。需要进一步研究来帮助优化 ABI,特别是针对不同的亚人群进行个性化定制,并研究其对长期公共卫生的影响。