Renan M J
Biosci Rep. 1986 Sep;6(9):819-25. doi: 10.1007/BF01117105.
In this study, the nucleotide sequences of the 3' untranslated regions (UTR) of the mouse and human c-fos genes, and the rat and human beta-actin genes were examined. It is shown (i) that the 3' UTR of c-fos is highly conserved between mouse and man, (ii) that multiple copies of a 12 bp element occur, in clusters, in the 3' UTR both of c-fos and of beta-actin. This conserved 12 bp element is analogous to the putative repressor binding site previously identified (Renan, Bioscience Reports, 5 (1985), 739-753). These findings provide additional support for the proposal that regulatory signals are located in the 3' UTR's of certain genes.
在本研究中，对小鼠和人类c-fos基因以及大鼠和人类β-肌动蛋白基因的3'非翻译区（UTR）的核苷酸序列进行了检测。结果表明：（i）c-fos的3'UTR在小鼠和人类之间高度保守；（ii）一个12bp元件的多个拷贝成簇地出现在c-fos和β-肌动蛋白的3'UTR中。这个保守的12bp元件类似于先前鉴定的假定阻遏物结合位点（雷南，《生物科学报告》，5（1985），739 - 753）。这些发现为调控信号位于某些基因的3'UTR这一观点提供了更多支持。
