Ruiz-Iglesias Patricia, Massot-Cladera Malén, Rodríguez-Lagunas Maria J, Franch Àngels, Camps-Bossacoma Mariona, Pérez-Cano Francisco J, Castell Margarida
Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona (UB), 08028 Barcelona, Spain.
Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 08921 Santa Coloma de Gramenet, Spain.
Antioxidants (Basel). 2022 Apr 10;11(4):753. doi: 10.3390/antiox11040753.
Intensive acute exercise can induce oxidative stress, leading to muscle damage and immune function impairment. Cocoa diet could prevent this oxidative stress and its consequences on immunity. Our aim was to assess the effect of a cocoa-enriched diet on the reactive oxygen species (ROS) production by peritoneal macrophages, blood immunoglobulin (Ig) levels, leukocyte counts, and the physical performance of rats submitted to an intensive acute exercise, as well as to elucidate the involvement of cocoa fiber in such effects. For this purpose, Wistar rats were fed either a standard diet, i.e., a diet containing 10% cocoa (C10), or a diet containing 5% cocoa fiber (CF) for 25 days. Then, half of the rats of each diet ran on a treadmill until exhaustion, and 16 h later, the samples were obtained. Both C10 and CF diets significantly prevented the increase in ROS production. However, neither the cocoa diet or the cocoa fiber-enriched diet prevented the decrease in serum IgG induced by acute exercise. Therefore, although the cocoa-enriched diet was able to prevent the excessive oxidative stress induced by intensive exercise, this was not enough to avoid the immune function impairment due to exercise.
高强度急性运动可诱发氧化应激，导致肌肉损伤和免疫功能受损。可可饮食可预防这种氧化应激及其对免疫的影响。我们的目的是评估富含可可的饮食对腹膜巨噬细胞产生活性氧（ROS）、血液免疫球蛋白（Ig）水平、白细胞计数以及进行高强度急性运动的大鼠体能的影响，并阐明可可纤维在此类影响中的作用。为此，将Wistar大鼠分别喂食标准饮食，即含10%可可的饮食（C10）或含5%可可纤维（CF）的饮食，持续25天。然后，每种饮食组的一半大鼠在跑步机上跑步直至精疲力竭，16小时后采集样本。C10和CF饮食均显著预防了ROS产生的增加。然而，可可饮食和富含可可纤维的饮食均未预防急性运动诱导的血清IgG降低。因此，尽管富含可可的饮食能够预防高强度运动诱导的过度氧化应激，但这不足以避免运动引起的免疫功能损害。
