Lawton Frank G, Pavlik Edward J
Gynaecological Cancer Surgeon South East London Gynaecological Cancer Centre, Guy's and St Thomas' NHS Trust, London SE1 7EH, UK.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Chandler Medical Center-Markey Cancer Center, Lexington, KY 40536, USA.
Diagnostics (Basel). 2022 Mar 24;12(4):791. doi: 10.3390/diagnostics12040791.
Unlike many other malignancies, overall survival for women with epithelial ovarian cancer has improved only modestly over the last half-century. The perspectives presented here detail the views of a gynecologic oncologist looking back and the view of the academic editor looking forward. Surgical beginnings in 1809 are merged with genomics, surgical advances, and precision therapy at present and for the future. Presentations in this special issue focus on factors related to the diagnosis of ovarian cancer: (1) markers for the preoperative assessment of primary and metastatic ovarian tumors, (2) demonstrations of the presence of pelvic fluid in ultrasound studies of ovarian malignancies, (3) the effects of age, menopausal status, and body habitus on ovarian visualization, (4) the ability of OVA1 to detect ovarian cancers when Ca125 was not informative, (5) the detection of tumor-specific changes in cell adhesion molecules by tissue-based staining, (6) presentation of a high discrimination model for ovarian cancer using IOTA Simple Rules and CA125, (7) review of low-grade serous carcinoma of the ovary, and (8) a comprehensive case report on ovarian carcinosarcoma.
与许多其他恶性肿瘤不同，上皮性卵巢癌女性患者的总体生存率在过去半个世纪中仅略有提高。此处呈现的观点详细阐述了一位妇科肿瘤学家的回顾性看法以及学术编辑的前瞻性看法。1809年的外科手术开端与当前及未来的基因组学、手术进展和精准治疗相结合。本期特刊的文章聚焦于与卵巢癌诊断相关的因素：（1）原发性和转移性卵巢肿瘤术前评估的标志物；（2）卵巢恶性肿瘤超声检查中盆腔积液存在情况的展示；（3）年龄、绝经状态和体型对卵巢可视化的影响；（4）当Ca125无诊断价值时OVA1检测卵巢癌的能力；（5）通过组织染色检测细胞黏附分子中肿瘤特异性变化；（6）使用IOTA简单规则和CA125的卵巢癌高鉴别模型介绍；（7）卵巢低级别浆液性癌综述；（8）卵巢癌肉瘤综合病例报告。
