Mitrovic-Jovanovic Milica, Grubor Nikica, Milosevic Stefan, Jankovic Aleksandra, Stosic Katarina, Ostojic Slavenko, Ninic Aleksandar, Micev Marjan, Djokic Kovac Jelena
Center for Radiology and Magnetic Resonance Imaging, University Clinical Centre of Serbia, Pasterova No. 2, 11000 Belgrade, Serbia.
Department for HBP Surgery, Clinic for Digestive Surgery, University Clinical Centre of Serbia, Koste Todorovica Street No. 6, 11000 Belgrade, Serbia.
Diagnostics (Basel). 2022 Apr 15;12(4):1003. doi: 10.3390/diagnostics12041003.
Pancreatic neuroendocrine tumors (PNETs) are uncommon pancreatic neoplasms with malignant potential, heterogeneous clinical behavior, as well as imaging appearance. These tumors represent less than 3% of all pancreatic neoplasms with typical CT presentation as solid, well-circumscribed, hypervascular lesions. Cystic PNET is a rare pancreatic tumor which is nowadays more often detected due to the widespread use of high-resolution cross-sectional imaging. They are mainly solitary lesions most commonly localized in the body and the tail of the pancreas. Due to cystic presentation these lesions often present a diagnostic challenge to both experienced radiologists and pathologists. Herein, we present a rare case of synchronous, multiple cystic and solid pancreatic neuroendocrine tumors, which due to their extensiveness required total dudenopancreatectomy with splenectomy. Histopathological findings confirmed microscopic and macroscopic cystic components as well as typical solid variants of neuroendocrine tumors along the entire pancreas.
胰腺神经内分泌肿瘤（PNETs）是一种少见的具有恶性潜能、临床行为异质性以及影像学表现各异的胰腺肿瘤。这些肿瘤在所有胰腺肿瘤中占比不到3%，典型的CT表现为实性、边界清晰、血供丰富的病变。囊性PNET是一种罕见的胰腺肿瘤，由于高分辨率横断面成像的广泛应用，如今更常被检测到。它们主要为孤立性病变，最常见于胰腺体部和尾部。由于呈囊性表现，这些病变常常给经验丰富的放射科医生和病理科医生带来诊断挑战。在此，我们报告一例罕见的同步发生的多发性囊性和实性胰腺神经内分泌肿瘤病例，由于其病变范围广泛，需要行十二指肠胰腺全切除术并脾切除术。组织病理学检查结果证实，整个胰腺均存在微观和宏观的囊性成分以及神经内分泌肿瘤的典型实性变体。
