Saltarella Ilaria, Apollonio Benedetta, Lamanuzzi Aurelia, Desantis Vanessa, Mariggiò Maria Addolorata, Desaphy Jean-François, Vacca Angelo, Frassanito Maria Antonia
Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
Department of Biomedical Sciences and Human Oncology, Pharmacology Section, University of Bari Medical School, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
Cancers (Basel). 2022 Apr 13;14(8):1963. doi: 10.3390/cancers14081963.
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides that are not translated into proteins. Nowadays, lncRNAs are gaining importance as key regulators of gene expression and, consequently, of several biological functions in physiological and pathological conditions, including cancer. Here, we point out the role of lncRNAs in the pathogenesis of multiple myeloma (MM). We focus on their ability to regulate the biological processes identified as "hallmarks of cancer" that enable malignant cell transformation, early tumor onset and progression. The aberrant expression of lncRNAs in MM suggests their potential use as clinical biomarkers for diagnosis, patient stratification, and clinical management. Moreover, they represent ideal candidates for therapeutic targeting.
长链非编码RNA（lncRNAs）是长度超过200个核苷酸且不翻译成蛋白质的转录本。如今，lncRNAs作为基因表达的关键调节因子正变得越来越重要，因此，在生理和病理状况（包括癌症）的多种生物学功能中也发挥着关键作用。在此，我们指出lncRNAs在多发性骨髓瘤（MM）发病机制中的作用。我们关注它们调节被确定为“癌症标志”的生物学过程的能力，这些过程能使恶性细胞发生转化、肿瘤早期发生和进展。MM中lncRNAs的异常表达表明它们有可能用作诊断、患者分层和临床管理的临床生物标志物。此外，它们是治疗靶点的理想候选者。
