芒果“Ataulfo”果皮提取物改善糖尿病前期Wistar大鼠的代谢失调。
Mango "Ataulfo" Peel Extract Improves Metabolic Dysregulation in Prediabetic Wistar Rats.
作者信息
Preciado-Saldaña Alejandra M, Domínguez-Avila Jesús Abraham, Ayala-Zavala Jesús Fernando, Astiazaran-Garcia Humberto F, Montiel-Herrera Marcelino, Villegas-Ochoa Mónica A, González-Aguilar Gustavo A, Wall-Medrano Abraham
机构信息
Coordinación de Tecnología de Alimentos de Origen Vegetal, Centro de Investigación en Alimentación y Desarrollo (CIAD), A. C. Carretera Gustavo Enrique Astiazarán Rosas No. 46, La Victoria, Hermosillo 83304, Sonora, Mexico.
Cátedras-CONACYT, Centro de Investigación en Alimentación y Desarrollo (CIAD), A. C. Carretera Gustavo Enrique Astiazarán Rosas No. 46, La Victoria, Hermosillo 83304, Sonora, Mexico.
出版信息
Life (Basel). 2022 Apr 5;12(4):532. doi: 10.3390/life12040532.
The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic rodents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory (α-amylase/α-glucosidase) activity. The polyphenolic MPE (138 mg EAG.g−1, mainly gallic acid and mangiferin) with antioxidant capacity (DPPH• 34 mgTE.g−1) was fed to PD rats (induction: high-fat diet (60% energy) + single dose streptozotocin (35 mg·kg−1), 4 weeks). At the 8th week, fasting glycemia (FG), oral glucose tolerance test, and insulin sensitivity indexes (HOMA-IR, HOMA-β) > blood lipid-normalizing effect were documented as healthy controls > MPE > disease (PD) controls, which was possibly related to the extract’s concentration−response in vitro enzyme inhibitory activity (IC50 ≈ 0.085 mg·mL−1). MPE is a rich source of glucose-lowering phytochemicals for the primary prevention of type 2 diabetes.
功能性植物化学物质的降血糖作用已在糖尿病啮齿动物中进行了评估，但在其发病前状态（糖尿病前期；PD）中却很少评估。本研究旨在评估芒果（品种：阿图尔福）果皮水乙醇（20:80）提取物（MPE）的体内血糖/血脂正常化作用以及体外酶抑制（α-淀粉酶/α-葡萄糖苷酶）活性。将具有抗氧化能力（DPPH• 34 mgTE.g−1）的多酚类MPE（138 mg EAG.g−1，主要为没食子酸和芒果苷）喂给PD大鼠（诱导：高脂饮食（60%能量）+单剂量链脲佐菌素（35 mg·kg−1），4周）。在第8周时，空腹血糖（FG）、口服葡萄糖耐量试验和胰岛素敏感性指标（HOMA-IR、HOMA-β）>血脂正常化作用记录为健康对照>MPE>疾病（PD）对照，这可能与提取物的体外酶抑制活性浓度-反应（IC50≈0.085 mg·mL−1）有关。MPE是用于2型糖尿病一级预防的丰富的降血糖植物化学物质来源。
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