小细胞外囊泡在炎症衰老中的作用机制

Action Mechanisms of Small Extracellular Vesicles in Inflammaging.

作者信息

Mato-Basalo Rocío, Lucio-Gallego Sergio, Alarcón-Veleiro Carmen, Sacristán-Santos Marta, Quintana María Del Pilar Miranda, Morente-López Miriam, de Toro Francisco Javier, Silva-Fernández Lucía, González-Rodríguez Alba, Arufe María C, Labora Juan Antonio Fafián

机构信息

Grupo de Investigación en Terapia Celular y Medicina Regenerativa, Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Ciencias de la Salud, Centro de Invesigaciones Científicas Avanzadas (CICA), Universidade da Coruña, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), 15006 A Coruña, Spain.

出版信息

Life (Basel). 2022 Apr 6;12(4):546. doi: 10.3390/life12040546.

DOI:10.3390/life12040546

PMID:35455036

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9028066/

Abstract

The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process. Recently, it has been reported that small extracellular vesicles (sEVs) are mediators in the transmission of paracrine senescence involved in inflammatory aging. For this reason, their components, as well as mechanisms of action of sEVs, are relevant to develop a new therapy called senodrugs (senolytics and senomorphic) that regulates the intercellular communication of inflammaging. In this review, we include the most recent and relevant studies on the role of sEVs in the inflammatory aging process and in age-related diseases such as cancer and type 2 diabetes.

摘要

衰老导致体内促炎成分的积累过程会影响细胞间通讯，这一现象被称为炎症衰老。这种生物学机制将炎症的发展与衰老过程联系起来。最近，有报道称小细胞外囊泡（sEVs）是参与炎症衰老的旁分泌衰老传递的介质。因此，它们的成分以及sEVs的作用机制，对于开发一种名为衰老药物（衰老溶解剂和衰老形态调节剂）的新疗法至关重要，该疗法可调节炎症衰老的细胞间通讯。在这篇综述中，我们纳入了关于sEVs在炎症衰老过程以及癌症和2型糖尿病等与年龄相关疾病中作用的最新且相关的研究。