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用于靶向治疗哮喘的纳米药物递送的药理学策略及最新进展

Pharmacological Strategies and Recent Advancement in Nano-Drug Delivery for Targeting Asthma.

作者信息

Ahmad Aftab

机构信息

Health Information Technology Department, Faculty of Applied Studies, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

出版信息

Life (Basel). 2022 Apr 18;12(4):596. doi: 10.3390/life12040596.

Abstract

With a high prevalence globally, asthma is a severe hazard to human health, as well as an economic and social burden. There are now novel therapies available for asthma with the use of nanotechnology. Recent developments in nanoscience and medicine have encouraged the creation of inhalable nanomedicines that can enhance the efficacy, patient compliance, and life quality for sufferers of asthma. Nanocarriers for asthma therapy, including liposomes, micelles, polymers, dendrimers, and inorganics, are presented in depth in this study as well as the current research status of these nanocarriers. Aerosolized nanomaterial-based drug transport systems are currently being developed, and some examples of these systems, as well as prospective future paths, are discussed. New research subjects include nano-modification of medicines and the development of innovative nano-drugs. Clinical experiments have proven that nanocarriers are both safe and effective. Before nanotherapy can be applied in clinical practice, several obstacles must be addressed. We look at some of the most recent research discoveries in the subject of nanotechnology and asthma therapy in this article.

摘要

哮喘在全球范围内发病率很高,对人类健康构成严重危害,同时也是一种经济和社会负担。目前,利用纳米技术可获得治疗哮喘的新疗法。纳米科学和医学的最新进展促使人们研发出可吸入的纳米药物,这些药物能够提高哮喘患者的治疗效果、患者依从性和生活质量。本研究深入介绍了用于哮喘治疗的纳米载体,包括脂质体、胶束、聚合物、树枝状大分子和无机物,以及这些纳米载体的当前研究现状。目前正在开发基于纳米材料雾化的药物输送系统,并讨论了这些系统的一些实例以及未来的潜在发展方向。新的研究课题包括药物的纳米改性和创新纳米药物的开发。临床试验已证明纳米载体既安全又有效。在纳米疗法应用于临床实践之前,必须克服几个障碍。在本文中,我们探讨了纳米技术与哮喘治疗领域的一些最新研究发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c16/9032250/dcf3a5c01135/life-12-00596-g001.jpg

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