Bates John T, Farmer Andrew P, Bierdeman Michael A, Ederer Dallas R, Carney Lauren S, Montgomery Denise D, Lirette Seth T, Marshall Gailen D
Department of Microbiology & Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Vaccines (Basel). 2022 Mar 25;10(4):512. doi: 10.3390/vaccines10040512.
Obesity is a significant factor for increased morbidity and mortality upon infection with SARS-CoV-2. Because of the higher potential for negative outcomes following infection of individuals with obesity, the impact of body mass index (BMI) on vaccine immunogenicity and efficacy is an important public health concern. Few studies have measured the magnitude and durability of the vaccine-specific response in relation to BMI. We measured the receptor binding domain (RBD)-specific serum IgG and surrogate neutralizing titers in a cohort of 126 vaccinated individuals with no clinical history or serological evidence of previous SARS-CoV-2 infection 50 and 200 days following vaccination. BMI had no significant impact on RBD-specific IgG titers and surrogate neutralizing titers 50 days following immunization, and leptin levels had no correlation with the response to immunization. Two hundred days following immunization, antibody titers in all groups had declined by approximately 90%. The responses were also similar between male and female participants and did not significantly vary across age groups. These results indicate that the magnitude and durability of the antibody response to mRNA-based vaccines are unaffected by BMI in this cohort.
肥胖是感染新冠病毒（SARS-CoV-2）后发病率和死亡率增加的一个重要因素。由于肥胖个体感染后出现负面结果的可能性更高，体重指数（BMI）对疫苗免疫原性和效力的影响是一个重要的公共卫生问题。很少有研究测量与BMI相关的疫苗特异性反应的强度和持久性。我们在126名无既往新冠病毒感染临床病史或血清学证据的接种疫苗个体队列中，于接种疫苗后50天和200天测量了受体结合域（RBD）特异性血清IgG和替代中和滴度。BMI在免疫后50天对RBD特异性IgG滴度和替代中和滴度没有显著影响，瘦素水平与免疫反应也没有相关性。免疫后200天，所有组的抗体滴度均下降了约90%。男性和女性参与者的反应也相似，且在各年龄组之间没有显著差异。这些结果表明，在该队列中，基于mRNA的疫苗的抗体反应强度和持久性不受BMI的影响。
