Wang Pan, Yang Nan, Xue Yuting, Zhou Jiansuo, Wu Yonghua, Wang Tiancheng, Cui Liyuan
Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China.
Core Unit of National Clinical Research Center for Laboratory Medicine, Beijing 100191, China.
Vaccines (Basel). 2022 Apr 7;10(4):571. doi: 10.3390/vaccines10040571.
Since 2019, the coronavirus disease 2019 (COVID-19) global pandemic has caused more than 300 million cases of disease and 5 million deaths. Vaccination has been widely accepted as the most effective measure for the prevention and control of this disease. However, there is little understanding about serum anti-SARS-CoV-2 IgM/IgG levels after inactivated vaccination as well as the relationship with peripheral blood leukocytes in the non-COVID-19 infected population. A total of 16,335 male and 22,302 female participants were recruited in this study, which was conducted in the Peking University Third Hospital located in Beijing (China). The level and seroprevalence of serum anti-SARS-CoV-2 receptor-binding domain (RBD) IgM/IgG and the association with peripheral blood leukocytes classification were investigated. With an increase in the number and percentage of full immunization of COVID-19 vaccinations in Beijing, serum anti-SARS-CoV-2 IgG antibodies levels and seroprevalence were significantly elevated (p < 0.01). The serum anti-SARS-CoV-2 IgG antibodies of 60 years and older persons were significantly lower than that of individuals that are 18~60 years old (p < 0.01), and there was a positive relationship between serum anti-SARS-CoV-2 IgG antibodies levels and peripheral blood lymphocyte count. The investigation of serum anti-SARS-CoV-2 IgM/IgG antibodies and the peripheral hematological index may prompt and help understand the adaptive immune response of vaccination.
自2019年以来，新型冠状病毒肺炎（COVID-19）全球大流行已导致超过3亿例病例和500万人死亡。疫苗接种已被广泛认为是预防和控制该疾病的最有效措施。然而，对于非COVID-19感染人群中灭活疫苗接种后的血清抗SARS-CoV-2 IgM/IgG水平以及与外周血白细胞的关系了解甚少。本研究共招募了16335名男性和22302名女性参与者，研究在北京（中国）的北京大学第三医院进行。研究了血清抗SARS-CoV-2受体结合域（RBD）IgM/IgG的水平和血清阳性率以及与外周血白细胞分类的关联。随着北京COVID-19疫苗全程接种数量和百分比的增加，血清抗SARS-CoV-2 IgG抗体水平和血清阳性率显著升高（p<0.01）。60岁及以上人群的血清抗SARS-CoV-2 IgG抗体显著低于18~60岁的个体（p<0.01），血清抗SARS-CoV-2 IgG抗体水平与外周血淋巴细胞计数呈正相关。对血清抗SARS-CoV-2 IgM/IgG抗体和外周血液学指标的调查可能有助于了解疫苗接种后的适应性免疫反应。
