Wang Ran, Jin Fang, Cao Shuhui, Yuan Hong, Qu Jingchen, Zhang Jiaqi, Li Yuxuan, Chen Xiangpeng, Song Wenqi, Xie Zhengde
Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases Key Laboratory of Major Diseases in Children Ministry of Education National Clinical Research Center for Respiratory Diseases Research Unit of Critical Infection in Children Chinese Academy of Medical Sciences 2019RU016, Laboratory of Infection and Virology Beijing Pediatric Research Institute Beijing Children's Hospital National Center for Children's Health Capital Medical University Beijing China.
Department of Laboratory Medicine Beijing Children's Hospital National Center for Children's Health Capital Medical University Beijing China.
Pediatr Investig. 2020 Dec 28;4(4):236-241. doi: 10.1002/ped4.12231. eCollection 2020 Dec.
In this study, we retrospectively investigated the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies within serum samples from children in Beijing, China. These findings provide preliminary guidance regarding population susceptibility to SARS-CoV-2, which will aid in establishing policy toward coronavirus disease 2019 (COVID-19) prevention and control.
To understand the seropositivity of anti-SARS-CoV-2 IgM/IgG antibodies among children in Beijing, China, evaluate the susceptibility of children in Beijing to SARS-CoV-2, and provide prima facie evidence to guide SARS-CoV-2 prevention and control.
IgM/IgG antibody kits (colloidal gold) were used to conduct preliminary screening of SARS-CoV-2 IgM/IgG antibodies in serum samples of children who presented to Beijing Children's Hospital, Capital Medical University, having fever or requiring hospitalization, from March 2020 to August 2020. Statistical analysis of anti-SARS-CoV-2 antibody seropositivity was performed according to the children's general demographic characteristics, timing of admission to hospital, presence of pneumonia, and viral nucleic acid test results.
The study included 19 797 children with both IgM and IgG antibody results. Twenty-four children had anti-SARS-CoV-2 IgM-positive results (positive rate of 1.2‰), twelve children had anti-SARS-CoV-2 IgG-positive results (positive rate of 0.6‰). Viral nucleic acid test results were negative for the above-mentioned children with positive antibody findings; during the study, two children exhibited positive viral nucleic acid test results, but their anti-SARS-CoV-2 IgM/IgG antibody results were negative. Anti-SARS-CoV-2 IgM antibody seropositivity was higher in the <1-year-old group than in the ≥6-year-old group. The rates of anti-SARS-CoV-2 IgM seropositivity was highest in August from March to August; IgG results did not significantly differ over time. The rates of anti-SARS-CoV-2 IgM or IgG seropositivity among children with and without suspected pneumonia did not significantly differ between groups.
During the study period, the rates of anti-SARS-CoV-2 IgM/IgG antibody seropositivity were low among children who presented to Beijing Children's Hospital, Capital Medical University. The findings suggest that children in Beijing are generally susceptible to SARS-CoV-2 infection; COVID-19 prevention and control measures should be strengthened to prevent disease in children.
在本研究中，我们回顾性调查了中国北京儿童血清样本中严重急性呼吸综合征冠状病毒2（SARS-CoV-2）抗体的血清流行率。这些发现为人群对SARS-CoV-2的易感性提供了初步指导，这将有助于制定针对2019冠状病毒病（COVID-19）预防和控制的政策。
了解中国北京儿童中抗SARS-CoV-2 IgM/IgG抗体的血清阳性情况，评估北京儿童对SARS-CoV-2的易感性，并提供初步证据以指导SARS-CoV-2的预防和控制。
使用IgM/IgG抗体检测试剂盒（胶体金法）对2020年3月至2020年8月期间到首都医科大学附属北京儿童医院就诊、发热或需要住院治疗的儿童血清样本中的SARS-CoV-2 IgM/IgG抗体进行初步筛查。根据儿童的一般人口统计学特征、入院时间、是否患有肺炎以及病毒核酸检测结果，对抗SARS-CoV-2抗体血清阳性情况进行统计分析。
该研究纳入了19797名同时有IgM和IgG抗体检测结果的儿童。24名儿童抗SARS-CoV-2 IgM检测结果为阳性（阳性率为1.2‰），12名儿童抗SARS-CoV-2 IgG检测结果为阳性（阳性率为0.6‰）。上述抗体检测阳性的儿童病毒核酸检测结果均为阴性；在研究期间，有2名儿童病毒核酸检测结果为阳性，但他们的抗SARS-CoV-2 IgM/IgG抗体检测结果为阴性。抗SARS-CoV-2 IgM抗体血清阳性率在<1岁组高于≥6岁组。3月至8月期间，抗SARS-CoV-2 IgM血清阳性率在8月最高；IgG结果随时间无显著差异。有和没有疑似肺炎的儿童中抗SARS-CoV-2 IgM或IgG血清阳性率在组间无显著差异。
在研究期间，到首都医科大学附属北京儿童医院就诊的儿童中抗SARS-CoV-2 IgM/IgG抗体血清阳性率较低。研究结果表明，北京儿童普遍易感染SARS-CoV-2；应加强COVID-19预防和控制措施以预防儿童患病。
