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达托霉素用于治疗极早早产儿心内膜炎——结局与展望

Daptomycin for Treatment of Endocarditis in an Extremely Preterm Neonate-Outcome and Perspectives.

作者信息

Minotti Chiara, Zuccon Ilaria, Priante Elena, Bonadies Luca, Di Chiara Costanza, Donà Daniele, Baraldi Eugenio, Costenaro Paola

机构信息

Department of Women's and Children's Health, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Neonatal Intensive Care Unit, Department of Women's and Children's Health, University Hospital of Padua, Via Giustiniani 2, 35128 Padua, Italy.

出版信息

Children (Basel). 2022 Mar 24;9(4):457. doi: 10.3390/children9040457.

DOI:10.3390/children9040457
PMID:35455502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9030184/
Abstract

With a considerable morbidity and mortality burden, infective endocarditis still represents a challenge for clinicians. This is a case of persistent endocarditis in an extremely preterm newborn. The infection, initially treated with vancomycin, was successfully cured with daptomycin. Its use was safe and effective, ensuring a complete remission without adverse effects.

摘要

感染性心内膜炎具有相当高的发病率和死亡率负担,仍然是临床医生面临的一项挑战。这是一例极早早产儿持续性心内膜炎的病例。该感染最初用万古霉素治疗,最终用达托霉素成功治愈。达托霉素的使用安全有效,确保了完全缓解且无不良反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdf/9030184/bc7f7b7b6b58/children-09-00457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdf/9030184/bc7f7b7b6b58/children-09-00457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdf/9030184/bc7f7b7b6b58/children-09-00457-g001.jpg

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Antibiotics (Basel). 2021 Feb 7;10(2):168. doi: 10.3390/antibiotics10020168.
2
Methicillin-Resistant Staphylococcus aureus Endovascular Infection in a Neonate: Prolonged, Safe, and Effective Use of Daptomycin and Enoxaparin.新生儿耐甲氧西林金黄色葡萄球菌血管内感染:达托霉素和依诺肝素的长期、安全和有效使用
J Pediatr Pharmacol Ther. 2020 Jan-Feb;25(1):68-74. doi: 10.5863/1551-6776-25.1.68.
3
The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants. An Evidence-based Approach.
治疗对关注的革兰氏阳性菌具有耐药性的儿童的治疗选择和结果:一项系统评价
Antibiotics (Basel). 2023 Jan 28;12(2):261. doi: 10.3390/antibiotics12020261.
支气管肺发育不良的诊断。基于循证的方法。
Am J Respir Crit Care Med. 2019 Sep 15;200(6):751-759. doi: 10.1164/rccm.201812-2348OC.
4
Trends in Infective Endocarditis in California and New York State, 1998-2013.1998 - 2013年加利福尼亚州和纽约州感染性心内膜炎的发病趋势
JAMA. 2017 Apr 25;317(16):1652-1660. doi: 10.1001/jama.2017.4287.
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Infective endocarditis in children: an update.儿童感染性心内膜炎:最新进展
Curr Opin Infect Dis. 2017 Jun;30(3):257-267. doi: 10.1097/QCO.0000000000000370.
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Successful Use of Daptomycin in a Preterm Neonate With Persistent Methicillin-Resistant Staphylococcus epidermidis Bacteremia.达托霉素成功用于一名患有持续性耐甲氧西林表皮葡萄球菌菌血症的早产儿
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8
High-dose daptomycin therapy for left-sided infective endocarditis: a prospective study from the international collaboration on endocarditis.高剂量达托霉素治疗左心感染性心内膜炎:国际心内膜炎协作组的前瞻性研究。
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