Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.
Institute for Systems Genomics, University of Connecticut, Farmington, CT 06030, USA.
Cells. 2022 Apr 14;11(8):1336. doi: 10.3390/cells11081336.
Obesity-induced adipose tissue dysfunction is bolstered by chronic, low-grade inflammation and impairs systemic metabolic health. Adipose tissue macrophages (ATMs) perpetuate local inflammation but are crucial to adipose tissue homeostasis, exerting heterogeneous, niche-specific functions. Diversified macrophage actions are shaped through finely regulated factors, including microRNAs, which post-transcriptionally alter macrophage activation. Numerous studies have highlighted microRNAs' importance to immune function and potential as inflammation-modulatory. This review summarizes current knowledge of regulatory networks governed by microRNAs in ATMs in white adipose tissue under obesity stress.
肥胖引起的脂肪组织功能障碍是由慢性低度炎症所支撑的，并损害全身代谢健康。脂肪组织巨噬细胞（ATMs）持续引发局部炎症，但对脂肪组织稳态至关重要，发挥着具有异质性和特定小生境的功能。巨噬细胞的多样化作用是通过精细调节的因素形成的，包括 microRNAs，它们通过转录后改变巨噬细胞的激活。许多研究强调了 microRNAs 在肥胖应激下白色脂肪组织中 ATMs 的免疫功能和作为炎症调节因子的潜力的重要性。这篇综述总结了 microRNAs 在肥胖应激下白色脂肪组织中 ATMs 调控网络的最新知识。
