Grolleau Sabrina, Delagrange Marine, Souquiere Melina, Molinas Catherine, Diene Gwenaëlle, Valette Marion, Tauber Maithé
French Reference Centre for Prader-Willi Syndrome and Other Rare Forms of Obesity with Eating Disorders, CHU Toulouse, 31059 Toulouse, France.
UMR 1027 INSERM, University Toulouse III, 31062 Toulouse, France.
J Clin Med. 2022 Apr 18;11(8):2255. doi: 10.3390/jcm11082255.
Our study aimed to evaluate the social deprivation score in families with a child with Prader-Willi syndrome (PWS) and analyze its impact on the occurrence of obesity in the affected child. We included 147 children with PWS followed in our reference center with Evaluation of the Deprivation and Inequalities of Health in Healthcare Centres by the EPICES score. Deprivation (EPICES ≥ 30) was found in 25.9% of the population. Compared with the non-obese children, children with obesity had more deprived families, 50.0 vs. 18.0% (p = 0.0001); were older, with a median of 10.1 vs. 6.0 years (p = 0.0006); were less frequently treated with growth hormone (GH), 80.6 vs. 91.9% (p = 0.07). The mothers of obese children were more frequently obese, 46.9 vs. 13.3% (p < 0.0001), and achieved high study levels less frequently (≥Bac+2), 40.9 vs. 70.1% (p = 0.012). The multivariate logistic regression indicated that age, living in a deprived family, and having a mother with overweight/obesity were significantly associated with an increased risk of obesity (respectively, OR = 3.31 (1.26−8.73) and OR = 6.76 (2.36−19.37)). The same risk factors of obesity observed in the general population were found in children with PWS. Families at risk, including social deprivation, will require early identification and a reinforced approach to prevent obesity.
我们的研究旨在评估患有普拉德-威利综合征（PWS）儿童的家庭社会剥夺得分，并分析其对患病儿童肥胖发生情况的影响。我们纳入了在我们参考中心随访的147名PWS儿童，采用EPICES评分评估医疗中心的剥夺和健康不平等情况。在25.9%的人群中发现了剥夺情况（EPICES≥30）。与非肥胖儿童相比，肥胖儿童的家庭剥夺情况更严重，分别为50.0%和18.0%（p = 0.0001）；年龄更大，中位数分别为10.1岁和6.0岁（p = 0.0006）；接受生长激素（GH）治疗的频率更低，分别为80.6%和91.9%（p = 0.07）。肥胖儿童的母亲肥胖的频率更高，分别为46.9%和13.3%（p < 0.0001），达到高学历水平（≥本科+2）的频率更低，分别为40.9%和70.1%（p = 0.012）。多因素逻辑回归表明，年龄、生活在剥夺家庭以及母亲超重/肥胖与肥胖风险增加显著相关（分别为OR = 3.31（1.26 - 8.73）和OR = 6.76（2.36 - 19.37））。在PWS儿童中发现了与普通人群中观察到的相同的肥胖风险因素。包括社会剥夺在内的高危家庭需要早期识别和强化干预措施以预防肥胖。
