Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Genes (Basel). 2022 Apr 13;13(4):681. doi: 10.3390/genes13040681.
Beta-lactam (BL) antibiotics are among the drugs commonly related to hypersensitivity reactions. Several candidate gene studies and genome-wide association studies have reported associations of genetic variants and hypersensitivity reactions induced by BL antibiotics. However, the results were inconclusive. This protocol details a comprehensive systematic review of genetic factors associated with BL-induced hypersensitivity. A systematic search of literature related to genetic associations of BL-induced hypersensitivity will be performed through PubMed, Medline, Scopus, EMBASE, Web of Science, CINAHL, and the Cochrane central register of Controlled Trials (CENTRAL) from their inception dates with no language restrictions. Two reviewers will independently screen, extract, and appraise the risk of bias. Frequencies of genetic variants that comply with Hardy-Weinberg equilibrium will be extracted and pooled. Genetic models will be applied to variant effect calculation as per allele and genotype analysis. Based on statistical heterogeneity among studies, common effect estimation (odds ratio) and its corresponding 95% confidence interval will be analyzed. Sensitivity and subgroup analyses will be performed to determine the robustness of eligible studies. This systematic review and meta-analysis will provide comprehensive evidence of genetic effects regarding BL-induced hypersensitivity. The findings will enlighten the determination of disease-related genotypes that would potentially reveal allergy profiling in patients.
β-内酰胺（BL）类抗生素是与过敏反应相关的常用药物之一。几项候选基因研究和全基因组关联研究报告了遗传变异与 BL 类抗生素引起的过敏反应之间的关联。然而，结果并不一致。本方案详细介绍了与 BL 诱导的过敏反应相关的遗传因素的综合系统评价。将通过 PubMed、Medline、Scopus、EMBASE、Web of Science、CINAHL 和 Cochrane 对照试验中心注册（CENTRAL）从其成立日期开始，不限制语言，对与 BL 诱导的过敏反应的遗传关联相关的文献进行系统搜索。两名审查员将独立筛选、提取和评估偏倚风险。将提取符合 Hardy-Weinberg 平衡的遗传变异的频率并进行汇总。根据研究之间的统计异质性，将分析常见效应估计（比值比）及其相应的 95%置信区间。将进行敏感性和亚组分析，以确定合格研究的稳健性。本系统评价和荟萃分析将提供关于 BL 诱导的过敏反应的遗传效应的综合证据。研究结果将阐明与疾病相关的基因型的确定，这可能会揭示患者的过敏特征。
