Yu Zhenfeng, He Yuanyuan, Schomann Timo, Wu Kefan, Hao Yang, Suidgeest Ernst, Zhang Hong, Eich Christina, Cruz Luis J
Translational Nanobiomaterials and Imaging Group, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Percuros B.V., Zernikedreef 8, 2333 CL Leiden, The Netherlands.
Pharmaceutics. 2022 Apr 11;14(4):840. doi: 10.3390/pharmaceutics14040840.
Nowadays, cancer poses a significant hazard to humans. Limitations in early diagnosis techniques not only result in a waste of healthcare resources but can even lead to delays in diagnosis and treatment, consequently reducing cure rates. Therefore, it is crucial to develop an imaging probe that can provide diagnostic information precisely and rapidly. Here, we used a simple hydrothermal method to design a multimodal imaging probe based on the excellent properties of rare-earth ions. Calcium fluoride co-doped with ytterbium, gadolinium, and neodymium (CaF:Y,Gd,Nd) nanoparticles (NPs) is highly crystalline, homogeneous in morphology, and displays a high biosafety profile. In addition, in vitro and ex vivo experiments explored the multimodal imaging capability of CaF:Y,Gd,Nd and demonstrated the efficient performance of CaF:Y,Gd,Nd during NIR-II fluorescence/photoacoustic/magnetic resonance imaging. Collectively, our novel diagnosis nanoparticle will generate new ideas for the development of multifunctional nanoplatforms for disease diagnosis and treatment.
如今，癌症对人类构成了重大危害。早期诊断技术的局限性不仅会导致医疗资源的浪费，甚至可能导致诊断和治疗的延误，从而降低治愈率。因此，开发一种能够精确、快速提供诊断信息的成像探针至关重要。在此，我们采用一种简单的水热法，基于稀土离子的优异特性设计了一种多模态成像探针。共掺杂镱、钆和钕的氟化钙（CaF:Y,Gd,Nd）纳米颗粒（NPs）具有高度结晶性，形态均匀，且具有高生物安全性。此外，体外和离体实验探究了CaF:Y,Gd,Nd的多模态成像能力，并证明了其在近红外二区荧光/光声/磁共振成像过程中的高效性能。总的来说，我们的新型诊断纳米颗粒将为开发用于疾病诊断和治疗的多功能纳米平台带来新的思路。
