Beijing Key Laboratory of Electrochemical Process and Technology of Materials, Beijing University of Chemical Technology, Beijing 100029, China.
State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China.
Int J Mol Sci. 2022 Apr 13;23(8):4279. doi: 10.3390/ijms23084279.
Two key concerns exist in contemporary cancer chemotherapy: limited therapeutic efficiency and substantial side effects in patients. In recent years, researchers have been investigating the revolutionary cancer treatment techniques of photodynamic therapy (PDT) and photothermal therapy (PTT) proposed by many scholars. A photothermal treatment of cancer was synthesized using the hydrothermal method which has high photothermal conversion efficiency and can generate reactive oxygen species (ROS) in cells. Photothermal treatment of tumors has a good short-term effect and photodynamic therapy lasts longer. However, both PTT and PDT have their inevitable shortcomings and it is difficult to completely eradicate a tumor using a single mode of treatment. PTT and PDT synergistic treatment not only inherits the advantages of low toxicity and side effects of phototherapy but also enables the two treatment methods to complement each other. It is an effective strategy to improve curative effects and reduce toxic and side effects. Furthermore, gold doped UCNPs have an exceptionally high target recognition for tumor cells. The gold doped UCNPs, in particular, are non-toxic to normal tissues, endowing the as-prepared medications with outstanding therapeutic efficacy and exceptionally low side effects. These findings may encourage the creation of fresh, effective imaging-guided approaches to meet the goal of photothermal cancer therapy.
治疗效率有限和患者的大量副作用。近年来，研究人员一直在研究许多学者提出的光动力疗法（PDT）和光热疗法（PTT）这两种革命性的癌症治疗技术。采用水热法合成了一种光热治疗癌症的方法，该方法具有较高的光热转换效率，能够在细胞中产生活性氧（ROS）。光热治疗肿瘤具有良好的短期效果，光动力疗法持续时间更长。然而，PTT 和 PDT 都有其不可避免的缺点，很难用单一的治疗模式完全根除肿瘤。PTT 和 PDT 协同治疗不仅继承了光疗低毒性和低副作用的优点，而且还使两种治疗方法相互补充。这是提高疗效、降低毒性和副作用的有效策略。此外，金掺杂 UCNPs 对肿瘤细胞具有极高的靶向识别能力。金掺杂 UCNPs 对正常组织无毒，赋予了所制备药物出色的治疗效果和极低的副作用。这些发现可能会鼓励创造新的、有效的成像引导方法，以实现光热癌症治疗的目标。
