Ola During Children's Hospital (ODCH) and Princess Christian Maternity Hospital (PCMH) Laboratory, Ministry of Health and Sanitation, Freetown 00232, Sierra Leone.
Department of Clinical Sciences, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.
Int J Environ Res Public Health. 2022 Apr 16;19(8):4865. doi: 10.3390/ijerph19084865.
In sub-Saharan Africa, there is limited information about the use of microbiology laboratory services in patients with suspected urinary tract infections (UTIs). This cross-sectional study assessed the requests for urine culture in patients with suspected UTI in two tertiary (maternal and paediatric) hospitals-Freetown and Sierra Leone, during May 2017-May 2021-and determined antimicrobial resistance (AMR) patterns among bacterial isolates. One laboratory served the two hospitals, with its electronic database used to extract information. Overall, there were 980 patients, of whom 168 (17%) had cultures requested and performed. Of these, 75 (45%) were culture positive. During 2017-2019, there were 930 patients, of whom 156 (17%) had cultures performed. During 2020-2021, when services were disrupted by the COVID-19 pandemic, there were 50 patients, of whom 12 (24%) had cultures performed. The four commonest isolates were (36), (10), (9), and spp. (6). There were high levels of AMR, especially for trimethoprim-sulfamethoxazole (47%), nalidixic acid (44%), nitrofurantoin (32%) and cefotaxime (36%). Overall, 41 (55%) bacterial isolates showed multidrug resistance, especially (58%), spp. (50%), and (44%). These findings support the need for better utilization of clinical microbiology services to guide antibiotic stewardship and monitoring of trends in resistance patterns.
在撒哈拉以南非洲，关于疑似尿路感染 (UTI) 患者使用微生物学实验室服务的信息有限。本横断面研究评估了 2017 年 5 月至 2021 年 5 月期间在塞拉利昂弗里敦的两家三级（孕产妇和儿科）医院中疑似 UTI 患者的尿液培养申请，并确定了细菌分离株的抗菌药物耐药性 (AMR) 模式。一个实验室为两家医院提供服务，其电子数据库用于提取信息。总体而言，共有 980 名患者，其中 168 名（17%）患者提出并进行了培养。其中，75 名（45%）培养阳性。2017-2019 年期间，有 930 名患者，其中 156 名（17%）进行了培养。2020-2021 年期间，由于 COVID-19 大流行服务中断，有 50 名患者，其中 12 名（24%）进行了培养。最常见的四种分离株分别为 （36%）、 （10%）、 （9%）和 spp.（6%）。存在高水平的 AMR，特别是对甲氧苄啶-磺胺甲恶唑（47%）、萘啶酸（44%）、呋喃妥因（32%）和头孢噻肟（36%）。总体而言，41 株（55%）细菌分离株表现出多药耐药性，特别是 （58%）、 spp.（50%）和 （44%）。这些发现支持更好地利用临床微生物学服务来指导抗生素管理和监测耐药模式的趋势。
