Neurovirosis Service at Virology Department, INEI-ANLIS, Dr. Carlos G. Malbran Institute, Argentina.
Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
Virology. 2019 May;531:79-92. doi: 10.1016/j.virol.2019.02.012. Epub 2019 Feb 18.
Echovirus 30 (E30) is an important causative agent of aseptic meningitis worldwide. Despite this, the global and regional dispersion patterns, especially in South America, are still largely unknown. We performed an in-depth analysis of global E30 population dynamics, by using the VP1 sequences of 79 strains isolated in Argentina, between 1998 and 2012, and 856 sequences from GenBank. Furthermore, the 3D regions of 329 sequences were analyzed to study potential recombination events. E30 evolution was characterized by co-circulation and continuous replacement of lineages over time, where four lineages appear to circulate at present and another four lineages appear to have stopped circulating. Five lineages showed a global distribution, whereas three other lineages had a more restricted circulation pattern. Strains isolated in South America belong to lineages E and F. Analysis of the 3D region of Argentinean strains indicated that recombination events occurred in both lineages.
肠病毒 30 型（E30）是全球无菌性脑膜炎的重要致病因子。尽管如此，其在全球和区域的分布模式，特别是在南美洲，仍然很大程度上不为人知。我们通过分析阿根廷在 1998 年至 2012 年间分离出的 79 株病毒和从 GenBank 中获取的 856 个序列的 VP1 序列，对全球 E30 人群动态进行了深入分析。此外，我们还分析了 329 个序列的 3D 区，以研究潜在的重组事件。E30 的进化特点是随着时间的推移，谱系的共同传播和持续替代，目前有四个谱系在循环，另外四个谱系似乎已经停止循环。五个谱系呈全球分布，而另外三个谱系的循环范围则较为局限。在南美洲分离出的菌株属于谱系 E 和 F。对阿根廷菌株 3D 区的分析表明，重组事件发生在两个谱系中。
