V.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ostrovitianov Str. 1, 117997 Moscow, Russia.
Molecules. 2022 Apr 12;27(8):2475. doi: 10.3390/molecules27082475.
We sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolite profiles and found that they differed between pregnant women with and without preeclampsia. Lipids and sugars were identified as components of the metabolite profile that are likely to be associated with the development of preeclampsia. While PE was established only in the third trimester, a set of metabolites specific for the third trimester, including 2-(acetylamino)-1,5-anhydro-2-deoxy-4-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol, N-Acetyl-D-glucosaminyldiphosphodolichol, Cer(d18:0/20:0), and allolithocholic acid, was already traced in the first trimester. These components are also likely involved in lipid metabolism disorders and the development of oxidative stress.
我们试图确定从子痫前期患者的血浆样本中获得的特征代谢物图谱。直接高分辨率质谱法用于分析来自 79 名孕妇的样本，其中 34 名患有子痫前期。我们对代谢物图谱进行了比较分析，发现它们在患有和不患有子痫前期的孕妇之间存在差异。脂质和糖被确定为与子痫前期发展相关的代谢物图谱的组成部分。虽然 PE 仅在孕晚期建立，但一组特定于孕晚期的代谢物，包括 2-(乙酰氨基)-1,5-脱水-2-脱氧-4-O-β-D-半乳糖吡喃基-D-阿拉伯庚-1-烯糖醇、N-乙酰-D-葡糖胺二磷酸多萜醇、Cer(d18:0/20:0)和全胆酸，在孕早期就已经被追踪到。这些成分也可能参与脂质代谢紊乱和氧化应激的发展。
