Soška Vladimír
Vnitr Lek. 2022 Winter;68(1):54-57.
The concentration of total cholesterol has so far been part of the SCORE tables for estimating the risk of cardiovascular events; in the new SCORE2 tables, it has already been replaced by non-HDL-cholesterol. Total cholesterol continues to serve as a guide for the presence of dyslipoproteinemia and is necessary for the calculation of LDL-cholesterol and non-HDL-cholesterol. The importance of HDL-cholesterol as a separate risk factor is already limited, but it is necessary for the calculation of non-HDL-cholesterol and LDL-cholesterol. LDL-cholesterol remains an essential indicator of risk, it is needed for decision making and control of hypolipidemic therapy. Non HDL-cholesterol can be used as a therapy target instead of LDL-cholesterol. Triglycerides remain necessary for residual risk assessment, for the calculation of LDL-cholesterol and for the diagnosis of certain types of dyslipoproteinemias.
到目前为止，总胆固醇浓度一直是用于评估心血管事件风险的SCORE表格的一部分；在新的SCORE2表格中，它已被非高密度脂蛋白胆固醇所取代。总胆固醇仍然是血脂异常存在的一个指导指标，并且对于计算低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇是必要的。高密度脂蛋白胆固醇作为一个单独的风险因素的重要性已经有限，但它对于计算非高密度脂蛋白胆固醇和低密度脂蛋白胆固醇是必要的。低密度脂蛋白胆固醇仍然是一个重要的风险指标，它对于降脂治疗的决策和控制是必需的。非高密度脂蛋白胆固醇可以替代低密度脂蛋白胆固醇用作治疗靶点。甘油三酯对于残余风险评估、低密度脂蛋白胆固醇的计算以及某些类型血脂异常的诊断仍然是必要的。
