Post Graduation Program in Medicine and Health (PPgMS), Federal University of Bahia, Salvador, Brazil.
Research Laboratory in Infectious Diseases (LAPI), University Hospital Complex Professor Edgard Santos, Federal University of Bahia, Salvador, Brazil.
AIDS Res Hum Retroviruses. 2022 Aug;38(8):660-669. doi: 10.1089/AID.2021.0233. Epub 2022 May 24.
The introduction of highly active combined antiretroviral therapy (cART) has changed the management of HIV/AIDS, which is recognized as a chronic disease with relevant aspects, such as adherence and quality of life. This study aimed to compare clinical and demographic characteristics and health-related quality of life in people with adherence and non-adherence to cART. A cross-sectional study was carried out with 200 participants. The instruments used were the Adherence Follow-up Questionnaire, the Beck Depression Inventory-II, the 36-Item Short Form Health Survey and the WHOQOL-HIV BREF. Poisson regression was applied to obtain estimates of adjusted prevalence ratios (PR). Individuals lacking therapeutic support were more likely to be non-adherent than those with proper support (PR: 1.79). The health-related quality of life of individuals with non-adherence was 4% lower (PR = 0.96) in the general health domain than individuals with adherence. Non-adherence to cART was associated with lower quality of life in the general health domain and no therapeutic support.
高效抗逆转录病毒疗法（cART）的引入改变了 HIV/AIDS 的管理方式，HIV/AIDS 被认为是一种慢性病，涉及到诸如依从性和生活质量等方面。本研究旨在比较依从和不依从 cART 的患者的临床和人口统计学特征以及与健康相关的生活质量。这是一项横断面研究，共纳入了 200 名参与者。使用的工具包括依从性随访问卷、贝克抑郁量表第二版、36 项简明健康调查问卷和世界卫生组织生活质量 HIV 简表。应用泊松回归来获得调整后的患病率比（PR）的估计值。与获得适当支持的患者相比，缺乏治疗支持的患者更有可能不依从（PR：1.79）。不依从 cART 的患者在一般健康领域的生活质量比依从患者低 4%（PR=0.96）。不依从 cART 与一般健康领域的生活质量较低和缺乏治疗支持有关。
