Chait Alan, Feingold Kenneth R
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA.
University of California San Francisco, San Francisco, CA, USA.
Best Pract Res Clin Endocrinol Metab. 2023 May;37(3):101659. doi: 10.1016/j.beem.2022.101659. Epub 2022 Apr 11.
Elevated triglyceride levels increase the risk of arteriosclerotic cardiovascular disease (ASCVD) and severely elevated triglyceride levels also increase the risk of triglyceride-induced pancreatitis. Although substantially reducing triglyceride levels will prevent pancreatitis, whether lowering triglycerides per se will reduce CVD risk is unclear. In this review, we outline several principles that will help in deciding who and how to treat patients with elevated triglyceride levels in order to prevent both ASCVD and pancreatitis. Using these principles will help in making decisions regarding the treatment of elevated triglyceride levels.
甘油三酯水平升高会增加动脉粥样硬化性心血管疾病（ASCVD）的风险，而甘油三酯水平严重升高还会增加甘油三酯诱导的胰腺炎风险。虽然大幅降低甘油三酯水平可预防胰腺炎，但降低甘油三酯本身是否会降低心血管疾病风险尚不清楚。在本综述中，我们概述了几条原则，这些原则将有助于决定哪些患者以及如何治疗甘油三酯水平升高的患者，以预防ASCVD和胰腺炎。运用这些原则将有助于就治疗甘油三酯水平升高做出决策。
