Medicine, Lister Hospital, Stevenage, UK.
Histopathology, Lister Hospital, Stevenage, Hertfordshire, UK.
BMJ Case Rep. 2022 Apr 22;15(4):e246341. doi: 10.1136/bcr-2021-246341.
A man in his mid-70s presented with a lump in his left testicle. He had previously been treated for prostate cancer with radical radiotherapy. He was on treatment for hypertension and type 2 diabetes. An ultrasound of the testes demonstrated a solid intratesticular mass for which he underwent left orchidectomy. Histology from the orchidectomy was moderately differentiated squamous cell carcinoma (SCC), positive for cytokeratin (CK) 5/6 and p63. A positron emission tomogram (PET) scan was clear of any metastatic disease. His surveillance CT, done at 12 months, revealed mediastinal, abdominal and hilar adenopathy. Biopsy of hilar lymph nodes showed SCC and this was treated with platinum-based chemotherapy. Unfortunately, the patient died after 18 months. To our knowledge, this is the first reported case of metastatic SCC of testes with extensive spread and with platinum-refractory disease.
一位 70 多岁的男性患者左侧睾丸处出现肿块。他曾因前列腺癌接受根治性放疗。他正在接受高血压和 2 型糖尿病的治疗。睾丸超声显示为实性睾丸内肿块，因此行左侧睾丸切除术。睾丸切除术的组织学为中分化鳞状细胞癌（SCC），细胞角蛋白（CK）5/6 和 p63 阳性。正电子发射断层扫描（PET）扫描未发现任何转移性疾病。他在 12 个月时进行的监测 CT 显示纵隔、腹部和肺门淋巴结肿大。肺门淋巴结活检显示 SCC，并用铂类为基础的化疗治疗。不幸的是，患者在 18 个月后死亡。据我们所知，这是首例报道的广泛转移和铂类耐药的睾丸 SCC 病例。
