Department of Dermatology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Department of Dermatology, University of California, Davis, Sacramento, CA, USA.
BMJ Case Rep. 2022 Apr 22;15(4):e249311. doi: 10.1136/bcr-2022-249311.
Granulocyte colony-stimulating factor (G-CSF) administration is associated with a diverse range of cutaneous sequelae. Serious dermatological side effects of G-CSF include the development of Sweet's syndrome and exacerbations of pre-existing inflammatory disorders such as psoriasis. Here, we describe a report of acute leucocytoclastic vasculitis caused by G-CSF therapy associated with anti-Ro and anti-La antibodies in a patient with multiple myeloma. This case highlights the importance of having a high index of suspicion for acute leucocytoclastic vasculitis in patients with haematological malignancies undergoing G-CSF therapy.
粒细胞集落刺激因子（G-CSF）的应用与多种皮肤后遗症有关。G-CSF 的严重皮肤副作用包括 Sweet 综合征的发展和先前存在的炎症性疾病如银屑病的恶化。在这里，我们描述了一例多发性骨髓瘤患者因 G-CSF 治疗引起的抗 Ro 和抗 La 抗体相关的急性白细胞碎裂性血管炎。该病例强调了对接受 G-CSF 治疗的血液恶性肿瘤患者的急性白细胞碎裂性血管炎保持高度怀疑的重要性。
