Zhang Muzi, Chen Xiaojun, Zhu Yong, Yin Lifeng, Quan Zhengxue, Ou Yunsheng, He Bin
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yi Xue Yuan Road, Yuzhong District, Chongqing, 400016, China.
Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Sci Rep. 2022 Apr 23;12(1):6689. doi: 10.1038/s41598-022-10586-1.
Circulating adiponectin shows some relationships with the occurrence of cardiometabolic diseases and osteoporotic fracture, but little is known about their causal associations. This two-sample Mendelian randomization (MR) study aims to explore the causal roles of circulating adiponectin in cardiometabolic diseases and osteoporotic fracture. We used 15 single nucleotide polymorphisms associated with circulating adiponectin as the instrumental variables. Inverse variance weighted, weighted median and MR-Egger regression methods were applied to study the causal associations. The results found that high circulating adiponectin was causally associated with reduced risk of type 2 diabetes (beta-estimate: -0.030, 95% CI: -0.048 to -0.011, SE: 0.009, P-value = 0.002) and may be the risk factor of coronary artery disease (beta-estimate: 0.012, 95% CI: 0.001 to 0.023, SE: 0.006, P-value = 0.030). No causal associations were seen between circulating adiponectin and other outcomes including heart failure, atrial fibrillation, cerebral ischemia, intracerebral hemorrhage or osteoporotic fracture. This study found the potential causal roles of high circulating adiponectin in reduced risk of type 2 diabetes and increased risk of coronary artery disease, which may help prevent and treat these two diseases.
循环脂联素与心脏代谢疾病和骨质疏松性骨折的发生存在一定关联，但其因果关系尚不清楚。这项两样本孟德尔随机化（MR）研究旨在探讨循环脂联素在心脏代谢疾病和骨质疏松性骨折中的因果作用。我们使用了15个与循环脂联素相关的单核苷酸多态性作为工具变量。采用逆方差加权、加权中位数和MR-Egger回归方法研究因果关联。结果发现，循环脂联素水平升高与2型糖尿病风险降低存在因果关系（β估计值：-0.030，95%置信区间：-0.048至-0.011，标准误：0.009，P值 = 0.002），且可能是冠状动脉疾病的危险因素（β估计值：0.012，95%置信区间：0.001至0.023，标准误：0.006，P值 = 0.030）。循环脂联素与其他结局（包括心力衰竭、心房颤动、脑缺血、脑出血或骨质疏松性骨折）之间未发现因果关联。本研究发现循环脂联素水平升高在降低2型糖尿病风险和增加冠状动脉疾病风险方面具有潜在因果作用，这可能有助于这两种疾病的防治。
