酒精和非酒精相关干扰：一项针对寻求治疗的酒精使用障碍成年患者的 fMRI 研究。
Alcohol- and non-alcohol-related interference: An fMRI study of treatment-seeking adults with alcohol use disorder.
机构信息
McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, United States.
McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.
出版信息
Drug Alcohol Depend. 2022 Jun 1;235:109462. doi: 10.1016/j.drugalcdep.2022.109462. Epub 2022 Apr 15.
BACKGROUND
Individuals with alcohol use disorder (AUD) have difficulty diverting attention away from alcohol-related stimuli and towards non-alcohol-related goals (i.e., alcohol-related attention interference). It remains unclear whether regulatory brain function differs during alcohol and non-alcohol-related interference. This study compares brain reactivity during the alcohol and classic Stroop and whether such brain function relates to AUD severity.
METHODS
46 participants with AUD completed alcohol and classic color-word Stroop tasks during fMRI. Brain activity was compared during alcohol and classic Stroop interference in the rostral and dorsal anterior cingulate cortices (rACC and dACC) and correlated with self-reported AUD severity. Exploratory whole-brain analyses were also conducted.
RESULTS
Behavioral interference (i.e., slower reaction times) was observed during alcohol and classic Stroop. rACC activity was significantly higher during the alcohol > neutral contrast versus the incongruent > congruent contrast. dACC activity did not differ between the Stroop tasks. dACC activity during incongruent > congruent was positively associated with AUD severity.
CONCLUSIONS
Activity in ACC subregions differed during alcohol and non-alcohol interference. Increased alcohol-related activity in the rACC, a region linked to emotional conflict resolution, suggests an interfering effect of self-relevant alcohol cues on non-alcohol-related processing. AUD severity was related to greater dACC reactivity during classic Stroop interference, suggesting that non-drug-related cognitive control impairments are more pronounced in those with more problematic alcohol use.
背景
患有酒精使用障碍（AUD）的个体难以将注意力从与酒精相关的刺激转移到与非酒精相关的目标（即，与酒精相关的注意力干扰）。目前尚不清楚在与酒精和非酒精相关的干扰过程中调节大脑功能是否存在差异。本研究比较了在酒精和经典 Stroop 任务期间大脑的反应性，以及这种大脑功能是否与 AUD 严重程度有关。
方法
46 名 AUD 患者在 fMRI 期间完成了酒精和经典颜色词 Stroop 任务。在额前扣带皮质（rACC 和 dACC）的额部和背部分别比较了酒精和经典 Stroop 干扰期间的大脑活动，并与自我报告的 AUD 严重程度相关。还进行了探索性的全脑分析。
结果
在酒精和经典 Stroop 任务中观察到行为干扰（即反应时间较慢）。rACC 在酒精 > 中性对比与不一致 > 一致对比期间的活性明显更高。Stroop 任务之间的 dACC 活性没有差异。dACC 在不一致 > 一致时的活动与 AUD 严重程度呈正相关。
结论
在酒精和非酒精干扰期间，ACC 亚区的活动不同。rACC 中与情绪冲突解决相关的与酒精相关的活动增加，表明自我相关的酒精线索对非酒精相关处理具有干扰作用。在经典 Stroop 干扰期间，dACC 的反应性与 AUD 严重程度相关，这表明与非药物相关的认知控制缺陷在那些酒精使用问题更严重的人中更为明显。
Zotero 插件